Liquid Biopsy Promotes Precision Medicine By Tracking Patient’s Cancer

In a study published in Nature Communications, Dr. Muhammed Murtaza, who holds a joint appointment at Mayo Clinic and Translational Genomics Research Institute (TGEN), and colleagues, describe an extensive comparison between biopsy results and analysis of ctDNA in a patient with breast cancer.

In the following video, Dr. Murtaza describes how circulating tumor DNA in blood could inform physicians on best treatments for individual patients.

For more information, visit:
►Mayo Clinic Center for Individualized Medicine: http://mayoresearch.mayo.edu/center-for-individualized-medicine/?mc_id=us&utm_source=youtube&utm_medium=sm&utm_content=video&utm_campaign=mayoclinic&geo=national&placementsite=enterprise&cauid=100504
►TGEN: https://tgen.org/home/news/2015-media-releases/tgen-shows-liquid-biopsies-could-help-cancer-patients.aspx#.VjooyWdRGUl

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Vitamin D Toxicity Rare in People Who Take Supplements, Mayo Clinic Researchers Report



Over the past decade, numerous studies have shown that many Americans have low vitamin D levels and as a result, vitamin D supplement use has climbed in recent years. Vitamin D has been shown to boost bone health and it may play a role in preventing diabetes, cancer, cardiovascular disease and other illnesses. In light of the increased use of vitamin D supplements, Mayo Clinic researchers set out to learn more about the health of those with high vitamin D levels. They found that toxic levels are actually rare.
Their study appears in the May issue of Mayo Clinic Proceedings. For more information, see the Mayo Clinic News Network: http://newsnetwork.mayoclinic.org/

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Lung Regeneration

There are hundreds of thousands of patients in the United States with end stage lung disease. Many of them are not candidates for lung transplantation or other therapies. Learn now lung regeneration, through the use of existing cells to build an artificial lung, is building a brighter future for patients with few treatment options.

To request an appointment, visit http://www.mayoclinic.org/departments-centers/transplant-center/lung-transplant/choosing-mayo-clinic/appointments-referrals?mc_id=us&utm_source=youtube&utm_medium=sm&utm_content=video&utm_campaign=mayoclinic&geo=national&placementsite=enterprise&cauid=100504

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Sticks and Stones Break Bones, So Does the Silent Disease Osteoporosis

The World Osteoporosis Day (WOD) 2018 campaign calls for global action to improve bone health and prevent fractures due to osteoporosis, including vertebral (spine) fractures — which often remain undiagnosed and untreated.  The public, healthcare professionals and organizations worldwide are joining together to raise awareness of bone health and call for action on osteoporosis and fracture prevention in their communities.

Facts About Osteoporosis

  • Osteoporosis is ahidden, underlying cause of painful, debilitating and life-threatening fractures
  • The most common of osteoporotic fractures are spine (vertebral) fractures, a major cause of pain, disability and loss of quality of life
  • Up to 70% of spine fractures remain undiagnosed, leaving sufferers unprotected against the high risk of more fractures
  • Back pain, height-loss and stooped back are all possible signs of spine fractures – ask for testing and treatment!
  • A family history of osteoporosis and broken bones is a sign that you too may be at higher risk
  • Osteoporosis is a growing global problem that respects no boundaries: worldwide, fractures affect one in three women and one in five men over the age of 50.

 

What is Osteoporosis

Osteoporosis causes bones to become weak and brittle — so brittle a fall or even mild stresses, such as bending over or coughing, can cause a fracture. Osteoporosis-related fractures most commonly occur in the hip, wrist or spine.

Bone is living tissue that is constantly being broken down and replaced. Osteoporosis occurs when the creation of new bone doesn’t keep up with the removal of old bone.

Osteoporosis affects men and women of all races. But white and Asian women — especially older women who are past menopause — are at highest risk. Medications, healthy diet and weight-bearing exercise can help prevent bone loss or strengthen already weak bones.

 

What are the symptoms of Osteoporosis

There typically are no symptoms in the initial stages of bone loss. But once your bones have been weakened by osteoporosis, you may have signs and symptoms that include:

  • Back pain, caused by a fractured or collapsed vertebra
  • Loss of height over time
  • A stooped posture
  • A bone fracture that occurs much more easily than expected

 

What causes Osteoporosis

Osteoporosis weakens bone.  Your bones are in a constant state of renewal — new bone is made, and old bone is broken down. When you’re young, your body makes new bone faster than it breaks down old bone and your bone mass increases. Most people reach their peak bone mass by their early 20s. As people age, bone mass is lost faster than it’s created.

How likely you are to develop osteoporosis depends partly on how much bone mass you attained in your youth. The higher your peak bone mass, the more bone you have “in the bank” and the less likely you are to develop osteoporosis as you age.

 

What are the risk factors of Osteoporosis?

A number of factors can increase the likelihood that you’ll develop osteoporosis — including your age, race, lifestyle choices, and medical conditions and treatments.

Unchangeable risks

Some risk factors for osteoporosis are out of your control, including:

  • Your sex. Women are much more likely to develop osteoporosis than are men.
  • Age. The older you get, the greater your risk of osteoporosis.
  • Race. You’re at greatest risk of osteoporosis if you’re white or of Asian descent.
  • Family history. Having a parent or sibling with osteoporosis puts you at greater risk, especially if your mother or father experienced a hip fracture.
  • Body frame size. Men and women who have small body frames tend to have a higher risk because they may have less bone mass to draw from as they age.
  • Hormone levels

Osteoporosis is more common in people who have too much or too little of certain hormones in their bodies. Examples include:

  • Sex hormones. Lowered sex hormone levels tend to weaken bone. The reduction of estrogen levels in women at menopause is one of the strongest risk factors for developing osteoporosis. Men experience a gradual reduction in testosterone levels as they age. Treatments for prostate cancer that reduce testosterone levels in men and treatments for breast cancer that reduce estrogen levels in women are likely to accelerate bone loss.
  • Thyroid problems. Too much thyroid hormone can cause bone loss. This can occur if your thyroid is overactive or if you take too much thyroid hormone medication to treat an underactive thyroid.
  • Other glands. Osteoporosis has also been associated with overactive parathyroid and adrenal glands.
  • Dietary factors

Osteoporosis is more likely to occur in people who have:

  • Low calcium intake. A lifelong lack of calcium plays a role in the development of osteoporosis. Low calcium intake contributes to diminished bone density, early bone loss and an increased risk of fractures.
  • Eating disorders. Severely restricting food intake and being underweight weakens bone in both men and women.
  • Gastrointestinal surgery. Surgery to reduce the size of your stomach or to remove part of the intestine limits the amount of surface area available to absorb nutrients, including calcium.
  • Steroids and other medications

Long-term use of oral or injected corticosteroid medications, such as prednisone and cortisone, interferes with the bone-rebuilding process. Osteoporosis has also been associated with medications used to combat or prevent:

  • Seizures
  • Gastric reflux
  • Cancer
  • Transplant rejection
  • Medical conditions

The risk of osteoporosis is higher in people who have certain medical problems, including:

  • Celiac disease
  • Inflammatory bowel disease
  • Kidney or liver disease
  • Cancer
  • Lupus
  • Multiple myeloma
  • Rheumatoid arthritis
  • Lifestyle choices

Some bad habits can increase your risk of osteoporosis. Examples include:

  • Sedentary lifestyle. People who spend a lot of time sitting have a higher risk of osteoporosis than do those who are more active. Any weight-bearing exercise and activities that promote balance and good posture are beneficial for your bones, but walking, running, jumping, dancing and weightlifting seem particularly helpful.
  • Excessive alcohol consumption. Regular consumption of more than two alcoholic drinks a day increases your risk of osteoporosis.
  • Tobacco use. The exact role tobacco plays in osteoporosis isn’t clearly understood, but it has been shown that tobacco use contributes to weak bones.

 

How does osteoporosis cause vertebrae to crumple and collapse?

Bone fractures, particularly in the spine or hip, are the most serious complication of osteoporosis. Hip fractures often are caused by a fall and can result in disability and even an increased risk of death within the first year after the injury.

In some cases, spinal fractures can occur even if you haven’t fallen. The bones that make up your spine (vertebrae) can weaken to the point that they may crumple, which can result in back pain, lost height and a hunched forward posture.

How can you prevent Osteoporosis?

Good nutrition and regular exercise are essential for keeping your bones healthy throughout your life.

Protein

Protein is one of the building blocks of bone. And while most people get plenty of protein in their diets, some do not. Vegetarians and vegans can get enough protein in the diet if they intentionally seek suitable sources, such as soy, nuts, legumes, and dairy and eggs if allowed. Older adults may also eat less protein for assorted reasons. Protein supplementation is an option.

Body weight

Being underweight increases the chance of bone loss and fractures. Excess weight is now known to increase the risk of fractures in your arm and wrist. As such, maintaining an appropriate body weight is good for bones just as it is for health in general.

Calcium

Men and women between the ages of 18 and 50 need 1,000 milligrams of calcium a day. This daily amount increases to 1,200 milligrams when women turn 50 and men turn 70. Reliable sources of calcium include:

  • Low-fat dairy products
  • Dark green leafy vegetables
  • Canned salmon or sardines with bones
  • Soy products, such as tofu
  • Calcium-fortified cereals and orange juice

If you find it difficult to get enough calcium from your diet, consider taking calcium supplements. However, too much calcium has been linked to kidney stones. Although yet unclear, some experts suggest that too much calcium especially in supplements can increase the risk of heart disease. The Institute of Medicine recommends that total calcium intake, from supplements and diet combined, should be no more than 2,000 milligrams daily for people older than 50.

Vitamin D

Vitamin D improves your body’s ability to absorb calcium and improves bone health in other ways. People can get adequate amounts of vitamin D from sunlight, but this may not be a reliable source if you live in a high latitude, if you’re housebound, or if you regularly use sunscreen or avoid the sun entirely because of the risk of skin cancer.

Scientists don’t yet know the optimal daily dose of vitamin D for each person. A good starting point for adults is 600 to 800 international units (IU) a day, through food or supplements. For people without other sources of vitamin D and especially with limited sun exposure, a supplement may be needed. Most multivitamin products contain between 600 and 800 IU of vitamin D. Up to 4,000 IU of vitamin D a day is safe for most people.

Exercise

Exercise can help you build strong bones and slow bone loss. Exercise will benefit your bones no matter when you start, but you’ll gain the most benefits if you start exercising regularly when you’re young and continue to exercise throughout your life.

Combine strength training exercises with weight-bearing and balance exercises. Strength training helps strengthen muscles and bones in your arms and upper spine, and weight-bearing exercises — such as walking, jogging, running, stair climbing, skipping rope, skiing and impact-producing sports — affect mainly the bones in your legs, hips and lower spine. Balance exercises such as tai chi can reduce your risk of falling especially as you get older.

Swimming, cycling and exercising on machines such as elliptical trainers can provide a good cardiovascular workout, but they’re not as helpful for improving bone health.

When to see a doctor

You may want to talk to your doctor about osteoporosis if you went through early menopause or took corticosteroids for several months at a time, or if either of your parents had hip fractures.

You’ll probably first bring your symptoms to the attention of your family doctor, who may refer you to a rheumatologist — a doctor specializing in the treatment of diseases of the joints, muscles and bone. To get the right help, find a rheumatologist or other physician who knows how hard it is to endure bone deteriation.  Go to HealthLynked.com today to build a Free patient profile and begin communicating there with those who will collaborate on your wellness.

Sources adapted from:

mayoclinic.org

 

 

How Minimally Invasive Laser Surgery Ended Epileptic Seizures – Mayo Clinic

Nicole Dehn, 30, has had epileptic seizures since she was six months old. Despite various medications and devices, her seizures remained uncontrolled. That is until Mayo Clinic offered hope with a new minimally invasive surgery. Known as laser thermal ablation, the therapy was previously approved by the U.S. Food and Drug Administration for treatment of tumors in other parts of the body, and is now being used for epilepsy patients. Early results are promising as Nicole is finally able to drive.

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Mayo Clinic Sports Medicine Center, Mayo Clinic Square Profile

Jonathan Finnoff, D.O., Medical Director for Mayo Clinic Square, Sports Medicine Center, Minneapolis, Minnesota discusses the services they provide in their program. Sports performance training, psychology, trainers for individuals and teams. Rehabilitation services with physical therapists who are specialized in sports medicine. Orthopedic surgeons and physiatrists with sports medicine training are also available. The center includes on-site musculoskeletal ultrasound, the Exos sports performance program and a regenerative medicine program. Mayo Clinic Square is ready to help athletes of all ages and levels of ability.

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New Balloon Therapy Lifts Weight Loss Burden

In the United States, two-thirds of the population is said to be either overweight or obese. Now there’s a new option for those who might need medical help to lose weight but don’t qualify for weight loss surgery. This week Mayo Clinic surgeons were the first in the U.S. to implant a new device recently approved by the FDA. The procedure involves the temporary placement of a special balloon in the stomach and has the potential for lasting results. Here’s Dennis Douda for the Mayo Clinic News Network.

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Immunotherapy and Triple Negative Breast Cancer – Mayo Clinic

A promising new study from Mayo Clinic, in conjunction with Caris Life Sciences, points to immunotherapy as a possible treatment option for patients with the difficult-to-treat triple negative breast cancer mutation. The study was presented this week at the 50th annual meeting of the American Society of Clinical Oncology in Chicago.

“This study may change our ability to treat triple negative breast cancer patients,” says Barbara Pockaj, M.D., lead investigator of the study and Mayo Clinic surgeon. “We may have signs that these patients can be treated with immunotherapy. We don’t have a lot of options for these patients and this would really expand our options.”

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“Our Father Taught Us” / A Journey Toward Teamwork – Preview

It all began with a country doctor and his sons—two boys raised to be doctors “the way farm boys are taught to be farmers.”

This film imagines Dr. William J. Mayo recalling an actual event from his childhood, when he and his brother, Charlie, accompanied their father on a journey to perform a difficult operation. On that memorable day, Will and Charlie learned the values of compassion, teamwork and dedication to the needs of the patient – values that became the foundation of Mayo Clinic.

Mayo Clinic Heritage Films produces original documentaries and dramatizations about key aspects of Mayo’s history. With the generous support of our benefactors, these award-winning films include cinematography of the highest quality; rare photos, movies and artifacts; and interviews with people who took part in historic events.

Enjoy these preview clips and visit http://store.mayoclinic.com/productList.cfm?mpc=6 to purchase the full-length DVD. Proceeds from the sale of each film support Mayo’s not-for-profit mission of excellence in patient care, research and education.

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