Loneliness – A Gene Deep Epidemic that Raises Health Risks and Can Be Spread

A 2016 survey of more than 2,000 American adults found 72 percent report having felt a sense of loneliness, with nearly a third (31 percent) experiencing loneliness at least once a week. The survey was conducted online by Harris Poll on behalf of the American Osteopathic Association in September.

Isolation is often an underlying factor in many of the most common health conditions, including chronic pain, substance abuse and depression, according to osteopathic physicians.

Long working hours, increased use of social media—in many cases surpassing in-person interaction—and a mobile workforce traveling or living far from family contribute to the high rates of loneliness, noted Jennifer Caudle, DO, assistant professor of family medicine at Rowan University School of Osteopathic Medicine.

“Loneliness is an invisible epidemic masked by our online personas, which are rarely representative of our real emotions,” said Dr. Caudle. “It’s important for patients to understand how their mental and emotional well-being directly affects the body. By taking a whole-person approach to care, osteopathic physicians are trained to address these underlying issues that can quietly erode patients’ health.”

Damage to the Immune Response

Research links loneliness to a number of dysfunctional immune responses, suggesting that being lonely has the potential to harm overall health.

In one study, researchers found that people who were more lonely showed signs of elevated latent herpes virus reactivation and produced more inflammation-related proteins in response to acute stress than did people who felt more socially connected.

These proteins signal the presence of inflammation, and chronic inflammation is linked to numerous conditions, including coronary heart disease, Type 2 diabetes, arthritis and Alzheimer’s disease, as well as the frailty and functional decline that can accompany aging.

Reactivation of a latent herpes virus is known to be associated with stress, suggesting that loneliness functions as a chronic stressor that triggers a poorly controlled immune response.

“It is clear from previous research that poor-quality relationships are linked to a number of health problems, including premature mortality and all sorts of other very serious health conditions. And people who are lonely clearly feel like they are in poor-quality relationships,” said Lisa Jaremka, a postdoctoral fellow at the Institute for Behavioral Medicine Research at Ohio State University and lead author of the research.

“One reason this type of research is important is to understand how loneliness and relationships broadly affect health. The more we understand about the process, the more potential there is to counter those negative effects – to perhaps intervene. If we don’t know the physiological processes, what are we going to do to change them?”

The results are based on a series of studies conducted with two populations: a healthy group of overweight middle-aged adults and a group of breast cancer survivors. The researchers measured loneliness in all studies using the UCLA Loneliness Scale, a questionnaire that assesses perceptions of social isolation and loneliness.

Jaremka presented the research at the Society for Personality and Social Psychology annual meeting in New Orleans.

The researchers first sought to obtain a snapshot of immune system behavior related to loneliness by gauging levels of antibodies in the blood that are produced when herpes viruses are reactivated.

Participants were 200 breast cancer survivors who were between two months and three years past completion of cancer treatment with an average age of 51 years. Their blood was analyzed for the presence of antibodies against Epstein-Barr virus and cytomegalovirus.

Both are herpes viruses that infect a majority of Americans. About half of infections do not produce illness, but once a person is infected, the viruses remain dormant in the body and can be reactivated, resulting in elevated antibody levels, or titers – again, often producing no symptoms but hinting at regulatory problems in the cellular immune system.

Lonelier participants had higher levels of antibodies against cytomegalovirus than did less lonely participants, and those higher antibody levels were related to more pain, depression and fatigue symptoms. No difference was seen in Epstein-Barr virus antibody levels, possibly because this reactivation is linked to age and many of these participants were somewhat older, meaning reactivation related to loneliness would be difficult to detect, Jaremka said.

Previous research has suggested that stress can promote reactivation of these viruses, also resulting in elevated antibody titers.

“The same processes involved in stress and reactivation of these viruses is probably also relevant to the loneliness findings,” Jaremka said. “Loneliness has been thought of in many ways as a chronic stressor – a socially painful situation that can last for quite a long time.”

In an additional set of studies, the scientists sought to determine how loneliness affected the production of proinflammatory proteins, or cytokines, in response to stress. These studies were conducted with 144 women from the same group of breast cancer survivors and a group of 134 overweight middle-aged and older adults with no major health problems.

Baseline blood samples were taken from all participants, who were then subjected to stress – they were asked to deliver an impromptu five-minute speech and perform a mental arithmetic task in front of a video camera and three panelists. Researchers followed by stimulating the participants’ immune systems with lipopolysaccharide, a compound found on bacterial cell walls that is known to trigger an immune response.

In both populations, those who were lonelier produced significantly higher levels of a cytokine called interleukin-6, or IL-6, in response to acute stress than did participants who were more socially connected. Levels of another cytokine, tumor necrosis factor-alpha, also rose more dramatically in lonelier participants than in less lonely participants, but the findings were significant by statistical standards in only one study group, the healthy adults.

In the study with breast cancer survivors, researchers also tested for levels of the cytokine interleukin 1-beta, which was produced at higher levels in lonelier participants.

When the scientists controlled for a number of factors, including sleep quality, age and general health measures, the results were the same.  “We saw consistency in the sense that more lonely people in both studies had more inflammation than less lonely people,” Jaremka said.

“It’s also important to remember the flip side, which is that people who feel very socially connected are experiencing more positive outcomes,” she said.

Loneliness Can Add 30 Points To Your Blood Pressure

In another study conducted at the Center for Cognitive and Social Neuroscience at the University of Chicago, researchers found that if you are over 50 and lonely, you could be adding 30 points to your blood pressure and raising significantly your chances of suffering from hypertension.   The increase in blood pressure due to loneliness was present after taking into account a person’s emotional state (how sad or stressed the person was).

The older the lonely person gets, the higher his/her blood pressure seems to get, said the researchers.   Lead researcher, Louise Hawkley, said “The take-home message is that feelings of loneliness are a health risk, in that the lonelier you are, the higher your blood pressure. And we know that high blood pressure has all kinds of negative consequences.”

229 people were monitored in this study, aged 50-68. The participants had to answer a questionnaire which determined each person’s level of loneliness.

Hawkley said it is not as simple as that. She said “Remember, people can feel lonely even if they are with a lot of people. You can think of Marilyn Monroe or Princess Diana – there was certainly nothing lacking in their social lives, yet they claimed to have felt intensely lonely. They may want to go out and make friends, and yet they have a nagging lack of trust with whomever they want to interact with, or they may feel hostile. So, they end up behaving in ways that force potential partners away.”

Loneliness Is Gene Deep

Loneliness has a molecular signature is reflected in the lonely person’s DNA. This was the conclusion of a new US study by scientists at the University of California Los Angeles (UCLA) and other US academic centers.

The study is published in an issue of the journal, Genome Biology.  The researchers discovered a distinct pattern of gene expression in immune cells of people who are chronically extremely lonely.

Study author Steve Cole, associate professor of medicine at the Division of Hematology and Oncology at the David Geffen School of Medicine at UCLA, member of the Cousins Center for Psychoneuroimmunology, and member of UCLA’s Jonsson Comprehensive Cancer Center said in a press release that:

“What this study shows is that the biological impact of social isolation reaches down into some of our most basic internal processes: the activity of our genes.”  Cole and colleagues suggest that feelings of isolation are linked to changes in gene expression that drive inflammation, one of the first responses of the immune system.  They hope the study gives a framework for understanding how social factors and increased risk of heart disease, viral infections and cancer are linked.

Scientists already know that social environments affect health. People who are lonely and socially isolated die earlier.  What they don’t know is if the higher rate of death among lonely people is because of reduced social resources or because of the effect of isolation on their bodily functions, or perhaps both.

However, Cole and the other researchers found that changes in the way immune cells express their genes were directly linked to the “subjective experience of social distance”.  The differences were independent of other known risk factors like health status, weight, age and use of medication, they said.  “The changes were even independent of the objective size of a person’s social network,” said Cole.

Cole and colleagues enrolled 14 participants from the Chicago Health, Aging, and Social Relations Study and scanned their DNA using a chip technology called DNA microarrays that allowed them to survey all known human genes in the samples.  6 of the participants scored in the top 15 per cent of a well known psychological test for loneliness that was developed in the 70s called the UCLA Loneliness Scale.  The remaining 8 participants scored in the bottom 15 per cent of the Loneliness Scale.

The DNA survey showed that 209 gene transcripts (where the gene gets its code ready to start making proteins) were expressed differently between the two groups. All the genes coded for leucocytes, agents of the immune system.  78 of the gene transcripts were “over expressed” (resulting in too much protein) and 131 were “under expressed” (not enough protein) in the lonely individuals compared to the others.

The over expressed genes included many that control immune system functions like inflammation.  However, it was also interesting that the under expressed genes were those involved in antiviral responses and production of antibodies.

“These data provide the first indication that human genome-wide transcriptional activity is altered in association with a social epidemiological risk factor. Impaired transcription of glucocorticoid response genes and increased activity of pro-inflammatory transcription control pathways provide a functional genomic explanation for elevated risk of inflammatory disease in individuals who experience chronically high levels of subjective social isolation.”

Distinguishing between the various aspects of loneliness that are closely linked to these changes in gene expression, the scientists discovered:  “What counts at the level of gene expression is not how many people you know, it’s how many you feel really close to over time,” said Cole.  He added that the findings could identify molecular targets for blocking the negative health impact of social isolation.

Loneliness Can Spread Through Social Networks

A US study of social networks found that a person’s loneliness can spread to others, in that when they become lonely they move to the edge of the network and transmit feelings of loneliness to their few remaining friends who also become lonely, leading to an effect that the researchers described as an unravelling at the edges of our social fabric.

The study, which was sponsored by the National Institute on Aging, is the work of John T Cacciopo of the University of Chicago, James H Fowler of the University of California, San Diego, and Nicholas A Christakis of Harvard University and is about to be published in the December issue of the Journal of Personality and Social Psychology.

Cacciopo, a social neuroscientist and lead investigator on the study, is Tiffany and Margaret Blake Distinguished Service Professor in Psychology at Chicago. He told the press that:

“We detected an extraordinary pattern of contagion that leads people to be moved to the edge of the social network when they become lonely.”

“On the periphery people have fewer friends, yet their loneliness leads them to losing the few ties they have left,” he added.

Loneliness is often associated with mental and physical diseases that can shorten life, said Cacioppo, so it is important for us to recognize it and help people reconnect with their social group before they move to the edges.

He and his co-authors wrote that while previous studies have already shown that a person’s loneliness and the number of people they are connected to in a network are linked, we don’t know much about “the placement of loneliness within, or the spread of loneliness through, social networks”.

Using longitudinal data from a large-scale study, they found that loneliness, like a bad cold, spreads in groups: people share their loneliness with others.

Cacioppo and colleagues used data on 5,124 people in the second generation of participants from the Framingham Heart Study, which has been tracking the health of individuals and their descendants for more than 60 years. The data set included information taken every two to four years on participants’ friends and social contacts.

For the study, Cacioppo and colleagues charted the friendship histories of participants and linked them to their reports of loneliness. This showed a pattern of loneliness that spread as people reported fewer close friends, and that lonely people appeared to transmit loneliness to others, and then moved to the edges of their social networks.

“Loneliness is disproportionately represented at the periphery of social networks and spreads through a contagious process,” wrote the researchers.

For example, one pattern might start when a participant reports one extra day a week of loneliness. This is followed by similar reports among his or her next-door neighbors who are also close friends. The pattern of loneliness then spreads as the neighbors spend less time together.

“These reinforcing effects mean that our social fabric can fray at the edges, like a yarn that comes loose at the end of a crocheted sweater,” explained Cacioppo.

The researchers also found that:

  • Women were more likely to report “catching loneliness from others” than men (perhaps reinforcing findings from studies that suggest women rely more on emotional support than men).
  • Loneliness occurred in clusters and extended up to three degrees of separation.
  • A person’s chances of reporting increased loneliness were more likely to be linked to changes in friendship networks than changes in family networks.

The authors concluded that the study helps us better understand the social forces that drive loneliness.

Society may benefit by “aggressively targeting the people in the periphery to help repair their social networks and to create a protective barrier against loneliness that can keep the whole network from unraveling,” they added.

Other studies suggest that as people become lonely they trust other people less and less, and this leads to a cycle of less trusting and more loneliness, which leads to less trusting, and so on, and as time goes by it becomes harder and harder to make friends.

Cacioppo said researchers have seen this social tendency reflected in monkey colonies that drive out members who have been removed and then reintroduced.  He said such a pattern makes it all the more important for us to recognize and offset loneliness before it spreads.

Overcoming Loneliness

The first step in addressing loneliness is to determine whether those feelings are caused by depression. A physician can diagnose any existing mental health conditions and suggest treatment options. To limit loneliness, physicians recommend some simple steps to help increase real social engagement:

  1. Consider a digital cleanse. Social networks can offer real connections, but the curated platforms may over-emphasize the success of others, which can lead to feelings of inadequacy. For more empowering activities, consider enrolling in a continuing education course or spending time enjoying nature.
  2. Exercise with others. Participating in a running club, group fitness course or team sport can have dual benefits, creating opportunities to meet new people while also improving physical health. Many sports stores, churches and community groups offer free weekly activities including fun runs and yoga.
  3. Buy local. Developing a routine that includes visiting a local shopkeeper, coffee shop, farmers’ market or gym builds roots in the community. Creating relationships with local vendors can lead to a sense of shared history and camaraderie.
  4. Step out of your comfort zone. Introducing yourself to nearby neighbors or engaging with people in the building elevator—while initially uncomfortable—can begin the process of developing community and has the added bonus of alleviating loneliness for others.
  5. Change jobs, schools or cities. This drastic option is not always possible, and certainly not easy, but it may have the most significant impact. Start by identifying the culture that would best fit your personality and work toward a transition.

“Face-to-face communication is critical for emotional and mental health,” Dr. Caudle added. “Seeking out meaningful human interactions makes patients happier and, ultimately, healthier overall.”

Conclusion

Loneliness has negative effects on your immune system, creates a genetic signature and can spread through social networks.  Our digital addictions seem to be contributing to our disconnectedness.  Additional studies indicate loneliness significantly shortens lives and can lead to or magnify dementia and Alzheimer’s.

Today is National Cheer up the Lonely Day.  Visit with the lonely and bring happy things to talk about. Keep the conversation upbeat, and lively. When you leave, give a big hug and let them know you enjoyed the stay. Sending cards or making a phone call is okay if they live too far away to visit, but what a lonely person really needs is face to face time with other people.

If you are feeling lonely, other studies indicate you are more likely to see a physician with increased frequency.  At HealthLynked, we can connect you to those physicians who really care and want to spend time with you.

To find a physician you really, well, click with, click on this link and get Lynked today!  It is free, and a great way for you to begin taking control of your health!

 

Adapted from:

[1] Caldwell, Emily. The Immune System Taxed By Loneliness, Similar To The Effect Of Chronic Stress.  Medical News Today, Tuesday 22 January 2013

This work was supported by grants from the National Institutes of Health, the American Cancer Society Postdoctoral Fellowship and a Pelotonia Postdoctoral Fellowship from Ohio State’s Comprehensive Cancer Center.

Co-authors include Christopher Fagundes of the Institute for Behavioral Medicine Research (IBMR); Juan Peng of the College of Public Health; Jeanette Bennett of the Division of Oral Biology; Ronald Glaser of the Department of Molecular Virology, Immunology and Medical Genetics; William Malarkey of the Department of Internal Medicine; and Janice Kiecolt-Glaser of the Department of Psychiatry, all at Ohio State. Bennett, Glaser, Malarkey and Kiecolt-Glaser are also IBMR investigators.

[2] Lombardi, Yvonne. Loneliness Can Add 30 Points To Your Blood Pressure If You Are Over 50.  Medical News Today. Wednesday, 29 March 2006.

[3] Paddock, Catharine PhD.  Loneliness Is Gene Deep. Medical News Today. Friday, 14 September 2007

“Effects of loneliness on gene expression.”
Cole SW, Hawkley LC, Arevalo JM, Sung CY, Rose RM, Cacioppo JT.
Genome Biology 2007, 8:R189.
doi:10.1186/gb-2007-8-9-r189
Published online 13 September 2007 (provisional version).

[4]  Paddock, Catharine PhD.  Loneliness Can Spread Through Social Networks.  Medical News Today. Wednesday, 2 December 2009

“Alone in the Crowd: The Structure and Spread of Loneliness in a Large Social Network.”
John T Cacciopo, James H Fowler, Nicholas A Christakis.
Journal of Personality and Social Psychology, December 2009 (pre-publication proof).
DOI:10.1037/a0016076

[5] American Osteopathic Association.  Survey Finds Nearly Three-Quarters (72%) of Americans Feel Lonely: Osteopathic Physicians Say Silent ‘Loneliness Epidemic’ Contributes to Nation’s Health Woes. PRN. Oct 11, 2016.

 

 

 

 

 

 

 

 

Is Working Long Hours Raising Your Risk for Diabetes?

Women who work 45 hours or more each week may be upping their risk of diabetes, new research finds. Men who work the same number of hours, however, are not affected.

While prior research has suggested a link between a long work week and an increased risk of diabetes, most of these studies focused on men.  Interestingly, this recent research seems to find the opposite effect in males: the longer the work week, the lower the incidence of diabetes.

For women who work 45 hours per week or more, though, their risk was considerably higher.  When compared with women who work 35–40 hours each week, they had a 63 percent higher risk of developing diabetes.

The authors of the new study, which was published in BMJ Open Diabetes Research and Care, looked at data from the 2003 Canadian Community Health survey, which included respondents aged 35–74.

They also looked at the Ontario Health Insurance Plan database for physician services, as well as the Canadian Institute for Health Information Discharge Abstract Database for hospital admissions.

In all, over 7,000 Canadian employees were included in the research. As well as looking at hours worked, the researchers also included other factors in their analysis, such as: sex, marital status, parenthood, ethnicity, place of birth, place of residence, long-term health conditions, lifestyle, weight, and body mass index (BMI).

They also considered unique workplace factors, such as shift work and the type of job the respondents did — for instance, whether it was predominantly active or sedentary.

Overall, the risk of diabetes was “only slightly reduced” when factors such as smoking and alcohol levels were considered.

While the researchers could not establish a definitive cause and effect from these data, they note that encouraging women to work fewer hours may be a key component of reducing the number of diabetes cases.

The shape of diabetes

Diabetes is a widespread issue around the world and impacts many lives. When someone has diabetes, their body does not utilize insulin properly; the pancreas increases production of the hormone until it can no longer keep up with the body’s demands.

This leads to higher-than-normal blood glucose levels and can eventually cause a wide range of problems throughout the body.

The American Diabetes Association say that over 30 million people in the United States have diabetes, and 7 million of these individuals are unaware of it.

Diabetes remains the seventh leading cause of death in the U.S., and, each year, doctors discover 1.5 million new cases. Worldwide, this number jumps to 425 million adults, with half remaining undiagnosed.

Diabetes prevention and management, then, are an essential facet of public health. Studies such as this one can help doctors to create guidelines that can positively impact the health of their patients and lead to fewer cases of diabetes down the road.

Limitations and next steps

Although the records used in this study did not distinguish between type 1 and type 2 diabetes, it is estimated that type 1 diabetes accounts for around 5 percent of cases among those aged 18 or over, so most of these cases were likely to be type 2.

In the future, if further studies agree with these findings, healthcare providers may recommend that women work 40 hours per week or under.

The study authors write, “Considering the rapid and substantial increase of diabetes prevalence…worldwide, identifying modifiable risk factors such as long work hours is of major importance to improve prevention and orient policy making, as it could prevent numerous cases of diabetes and diabetes-related chronic diseases.”


Ifworking long hours is causing you to feel poorly, consider talking to a physician.  You can quickly find and connect with one in the largest ever healthcare ecosystem designed to vastly improve the relationship doctors and patients are meant to enjoy and find great value in….

Ready to get Lynked?  Go to HealthLynked.com to sign up for Free and start taking control of your healthcare today!

Source:
Beyer, Monica. “Diabetes risk increased in women who work long hours.” Medical News Today. Sunday, 8 July 2018.

Is Eating Chocolate Actually Good for You? Researchers Seem to Think So!

Despite a bad rap for causing weight gain and loosely being associated with acne, Chocolate is the ultimate comfort food for many.  Americans spend $10 billion annually on chocolaty treats.  For many, it is a sure-fire relief in times of stress, a reliable source of consolation in times of disappointment, and a mood-enhancer and romance-magnifier in more positive circumstances.

But is it at all healthy?  If you consume lots of it, obviously not; but the next time you savor a piece of chocolate, you may not have to feel so guilty about it. Countless studies document a host of medically proven ways in which chocolate — good chocolate, which is to say dark chocolate, with a cocoa percentage of around seventy per cent or more — really is good for us.

Fast facts on chocolate

  • Chocolate is made from tropical Theobroma cacao tree seeds.
  • Its earliest use dates back to the Olmec civilization in Mesoamerica.
  • After the European discovery of the Americas, chocolate became very popular in the wider world, and its demand exploded.
  • Chocolate consumption has long been associated with conditions such as diabetes, coronary heart disease, and hypertension.
  • Chocolate is believed to contain high levels of antioxidants.
  • Some studies have suggested chocolate could lower cholesterol levels and prevent memory decline.
  • Chocolate contains a large number of calories.
  • People who are seeking to lose or maintain weight should eat chocolate only in moderation.

Benefits

Chocolate receives a lot of bad press because of its high fat and sugar content. Its consumption has also been associated high blood pressure, coronary artery disease, and diabetes.

However, a review of chocolate’s health effects published in the Netherlands Journal of Medicine point to the discovery that cocoa – the key ingredient in chocolate –  contains biologically active phenolic compounds.  This has changed people’s views on chocolate, and it has stimulated research into how it might impact aging, and conditions such as oxidative stress, blood pressure regulation, and atherosclerosis.

It is important to note many of the possible health benefits mentioned below are gleaned  from single studies.

1)  Cholesterol

One study, published in The Journal of Nutrition, suggests that chocolate consumption might help reduce low-density lipoprotein (LDL) cholesterol levels, also known as “bad cholesterol.”

The researchers set out to investigate whether chocolate bars containing plant sterols (PS) and cocoa flavanols (CF) have any effect on cholesterol levels.

The authors concluded: “Regular consumption of chocolate bars containing PS and CF, as part of a low-fat diet, may support cardiovascular health by lowering cholesterol and improving blood pressure.”

2)  Cognitive function

Scientists at Harvard Medical School have suggested that drinking two cups of hot chocolate a day could help keep the brain healthy and reduce memory decline in older people.

The researchers found that hot chocolate helped improve blood flow to parts of the brain where it was needed.

Lead author, Farzaneh A. Sorond, said:

“As different areas of the brain need more energy to complete their tasks, they also need greater blood flow. This relationship, called neurovascular coupling, may play an important role in diseases such as Alzheimer’s.”

Another study, published in 2016 in the journal Appetite, suggests eating chocolate at least once weekly could improve cognitive function.

Flavanols are thought to reduce memory loss in older people, and the anti-inflammatory qualities of dark chocolate have been found beneficial in treating brain injuries such as concussion.

Research has shown that when elderly people were given specially prepared cocoa extracts which was high in flavanols, their cognitive function greatly improved. The only problem is that when it comes to eating chocolate, the percentage of those cocoa flavanols is much reduced due to the processing and the addition of eggs, sugar and milk.

3)  Heart disease

Lots of studies reveal that the flavonoids in chocolate can help your veins and arteries to stay supple. Over 7 studies followed 114,000 participants who were given a few servings of dark chocolate a week. The results showed that their risk of getting a heart attack was reduced by about 37% while the chances of getting a stroke were 29% less when they had a higher consumption of chocolate.

Research published in The BMJ, suggests that consuming chocolate could help lower the risk of developing heart disease by one-third.  Based on their observations, the authors concluded that higher levels of chocolate consumption could be linked to a lower risk of cardiometabolic disorders.

A 2014 study found that dark chocolate helps restore flexibility to arteries while also preventing white blood cells from sticking to the walls of blood vessels – both common causes of artery clogging.

4)  Stroke

Canadian scientists, in a study involving 44,489 individuals, found that people who ate chocolate were 22 percent less likely to experience a stroke than those who did not. Also, those who had a stroke but regularly consumed chocolate were 46 percent less likely to die as a result.

A further study, published in the journal Heart in 2015, tracked the impact of diet on the long-term health of 25,000 men and women.  The findings suggested that eating up to 100 grams (g) of chocolate each day may be linked to a lower risk of heart disease and stroke.

5)  Good for moms, fetal growth and development

Eating 30 g of chocolate every day during pregnancy might benefit fetal growth and development, according to a study presented at the 2016 Pregnancy Meeting of the Society for Maternal-Fetal Medicine in Atlanta, GA.

A Finnish study also found that chocolate reduced stress in expectant mothers, and that the babies of such mothers smiled more often than the offspring of non-chocolate-eating parents.

One of the complications of pregnancy, known as preeclampsia, can cause blood pressure can shoot up. Researchers have established that one of the chemicals in dark chocolate, theobromine, can stimulate the heart and help the arteries dilate. When pregnant women were given higher doses of chocolate, they had a 40% less chance of developing this complication.

6)  Athletic performance

Findings published in The Journal of the International Society of Sports Nutrition suggest a little dark chocolate might boost oxygen availability during fitness training.

Another magical flavanol in chocolate is epicatechin. Mice were given this substance and they were much fitter and stronger than those mice on water only. Researchers say that to get the best results from your workout you have to limit the amount to only about half of one square of chocolate a day! If you have too much, it could undo the beneficial effects.

7)   It’s mineral rich

Dark chocolate is packed with beneficial minerals such as potassium, zinc and selenium, and a 100g bar of dark (70 per cent or more) choc provides 67 per cent of the RDA of iron.  It has almost all of your RDA for copper and manganese, contains over half your magnesium RDA and delivers about 10% of fiber.

8)  It reduces cholesterol

Consumption of cocoa has been shown to reduce levels of “bad” cholesterol (LDL) and raise levels of “good” cholesterol, potentially lowering the risk of cardiovascular disease.

The Journal of Nutrition published an interesting article about the results of a study done to determine whether dark chocolate could have any effect on the LDL cholesterol levels. They found when subjects were given bars of dark chocolate with plant sterols and flavanols, they were getting lower scores on their cholesterol levels.

9)  It’s good for your skin

The flavanols in dark chocolate can protect the skin against sun damage.     One study conducted in London found that women who were given chocolate with a high flavanol content were able to withstand double the amount of UV light on their skins without burning, compared to those on lower doses.  Still, you are probably better off slapping on some sunscreen.

10) It can help you lose weight

Chocolate can help you lose weight. Really. Neuroscientist Will Clower says a small square of good choc melted on the tongue 20 minutes before a meal triggers the hormones in the brain that say, “I’m full”, cutting the amount of food you subsequently consume. Finishing a meal with the same small trigger could reduce subsequent snacking.

11) It may prevent diabetes

It sounds mad, but cocoa has been shown to improve insulin sensitivity. So dark chocolate – in moderation – might delay or prevent the onset of diabetes. One small study at the University of L’Aquila in Italy found that the right does of chocolate flavonoids can help the body’s metabolism and enhance insulin function.

12) Chocolate makes you feel better

Chocolate contains phenylethylamine (PEA), which is the same chemical that your brain creates when you feel like you’re falling in love. PEA encourages your brain to release feel-good endorphins. These Endorphins play a key role in helping to prevent depression and other mental malaise.

Some chocolate lovers also add certain kinds of chocolate may be good for the soul: this is chocolate for which the raw materials have been grown with care by farmers who are properly rewarded for their work; then processed by people who take time and care in their work and finished by chocolatiers who love what they do. It is not mass-produced, and it may not be cheap. But it could be good for you, heart and soul.

13) It may help people with Alzheimer’s disease

As we know, the nerve pathways to the brain get damaged when Alzheimer’s disease strikes, causing severe loss in certain mental functions. It is fascinating to read about how one extract from cocoa, called lavado, can actually reduce the damage done to these vital pathways.

Results of a lab experiment, published in 2014, indicated that a cocoa extract, called lavado, might reduce or prevent damage to nerve pathways found in patients with Alzheimer’s disease. This extract could help slow symptoms such as cognitive decline.

14) It can help to lower your blood pressure

You may not know it but having the right amount of NO (Nitric Oxide) in your body can help your arteries to relax. That will, in turn help to take some of the pressure off them and the result is a lower BP count. Just another benefit of the dark chocolate flavanols which help to produce this vital Nitric Oxide.

15) It can also help you see better

University of Reading researchers were curious to see if dark chocolate flavanols could actually improve vision as they knew it certainly improved blood circulation in general. They decided to do a small experiment and gave two groups of volunteers some white and dark chocolate. The dark chocolate groups were doing better on vision tests afterwards.

16) It may help reduce fatigue

If you suffer from Chronic Fatigue Syndrome you should try adding chocolate to your daily diet. One group of sufferers were given a daily dose of chocolate for two months. They were less tired and the best news of all is that they did not put on any extra weight.

17) It may help to lower your Body Mass Index

There has been a lot of emphasis on how chocolate can actually reduce your BMI (Body Mass Index) which is how you measure up as regards your height versus your weight. One study took 1,000 Californians and they found that those who ate chocolate more often during the week had a lower BMI. Overall diet and exercise regimes were not factors which influenced this result.

18) It may help reduce your chances of getting cancer

As we have mentioned, the cocoa flavanols in dark chocolate have both anti-inflammatory and antioxidant properties. These are important in keeping the actions of free radicals at bay. As we know, these are the protagonists when cancer starts to invade cells.

19) It may help your cough

Another marvelous effect of the theobromine chemical in chocolate is that it can calm a troublesome cough. Manufacturers are looking at this to produce safer cough syrups instead of using codeine which has some undesirable side effects.

20) It may help with blood circulation

Normally you take an aspirin to help prevent blood clotting and to improve circulation. Studies now show that chocolate can have a similar effect.

Light vs. dark chocolate

Chocolate’s antioxidant potential may have a range of health benefits. The higher the cocoa content, as in dark chocolate, the more benefits there are. Dark chocolate may also contain less fat and sugar, but it is important to check the label.

Manufacturers of light, or milk, chocolate, claim their product is better for health because it contains milk, and milk provides protein and calcium. Supporters of dark chocolate point to the higher iron content and levels of antioxidants in their product.

How do the nutrients compare?

Here are some sample nutrient levels in light and dark chocolate,

Nutrient Light (100 g) Dark (100 g)
Energy 531 kcal 556 kcal
Protein 8.51 g 5.54 g
Carbohydrate 58 g 60.49 g
Fat 30.57 g 32.4 g
Sugars 54 g 47.56 g
Iron 0.91 mg 2.13 mg
Phosphorus 206 mg 51 mg
Potassium 438 mg 502 mg
Sodium 101 mg 6 mg
Calcium 251 mg 30 mg
Cholesterol 24 mg 5 mg

The darker the chocolate, the higher the concentration of cocoa, and so, in theory, the higher the level of antioxidants there will be in the bar.

However, nutrients vary widely in commercially available chocolate bars, depending on the brand and type you choose. It is best to check the label if you want to be sure of the nutrients.

Risks and precautions

More research is needed to confirm eating chocolate can really improve people’s health.  In addition, chocolate bars do not contain only cocoa. The benefits and risks of any other ingredients, such as sugar and fat, need to be considered.

Weight gain: Some studies suggest that chocolate consumption is linked to lower body mass index (BMI) and fatness. However, chocolate can have a high calorie count due to its sugar and fat content. Anyone who is trying to slim down or maintain their weight should limit their chocolate consumption and check the label of their favorite product.

Sugar content: The high sugar content of most chocolate can also be a cause of tooth decay.

Migraine risk: Some people may experience an increase in migraines when eating chocolate regularly due to cocoa’s tyramine, histamine, and phenylalanine content. However, research is mixed.

Bone health: There is some evidence that chocolate might cause poor bone structure and osteoporosis. The results of one study, published in The American Journal of Clinical Nutrition, found that older women who consumed chocolate every day had lower bone density and strength.

Heavy metals: Some cocoa powders, chocolate bars, and cacao nibs may contain high levels of cadmium and lead, which are toxic to the kidneys, bones, and other body tissues.

In 2017, Consumer Lab tested 43 chocolate products and found that nearly all cocoa powders contained more than 0.3 mcg cadmium per serving, the maximum amount recommended by the World Health Organization (WHO).

Conclusion

All in all, eating chocolate can have both health benefits and risks. As with anything, moderation is key.  Research is continuing, and while experts have already found chocolate is good for the heart, circulation and brain, it has been suggested it may even greater benefit in such major heath challenges as autism, obesity and  diabetes.

If you are interested in speaking with a physician about the delicious benefits of chocolate or starting a workout to shed the unwanted effects of too much, find a doctor in the nation’s largest healthcare social ecosystem – HealthLynked.  Here, patients a connecting with physicians in unique ways to Improve HealthCare.

Ready to get Lynked?  Go to HealthLynked.com to sign up for Free!

 

Sources:

20 Health Benefits of Chocolate, Robert Locke

Health benefits and risks of chocolate, Natalie Butler, RD, LD

 

How is Lack of Sleep Ruining Your Health?

I used to say, “I will sleep when I am dead.”  That’s Old military humor meant as some form of motivation in those days we would go for an eternity without sleep.  What I did not know was that not sleeping can draw us closer to death every day.

Ongoing surveys indicate more people are sleeping less than six hours a night, and sleep difficulties visit 75% of us at least a few nights per week. A short-lived bout of insomnia is generally nothing to worry about. The bigger concern is chronic sleep loss, which can contribute to health problems such as weight gain, high blood pressure, and a weakening in the immune system – all which can cause even greater problems down the road.

Why Is Sleep Important?

Sleep plays a vital role in good health and well-being throughout your life. Getting enough quality sleep at the right times can help protect your mental health, physical health, quality of life, and safety.

The way you feel while you’re awake depends in part on what happens while you’re sleeping. During sleep, your body is working to support healthy brain function and maintain your physical health. In children and teens, sleep also helps support growth and development.

Think of your body like a factory that performs a number of vital functions. As you drift off to sleep, your body begins its night-shift work:

  • Healing damaged cells
  • Boosting your immune system
  • Recovering from the day’s activities
  • Recharging your heart and cardiovascular system for the next day

Understanding the sleep cycle

Understanding what happens during sleep also means understanding the sleep cycle, which consists of  two recurring phases: REM (rapid eye movement) and NREM (non-REM or non-rapid eye movement). Both phases are important for different functions in our bodies.

NREM sleep typically occupies 75–80% of total sleep each night. Many of the health benefits of sleep take place during NREM sleep – tissue growth and repair occurs, energy is restored and hormones that are essential for growth and development are released.

REM sleep typically occupies 20–25% of total sleep each night. REM sleep, when dreaming occurs, is essential to our minds for processing and consolidating emotions, memories and stress. It is also thought to be vital for learning, stimulating the brain regions used in practicing and developing new skills.

If the REM and NREM cycles are interrupted multiple times throughout the night — either due to snoring, difficulties breathing or waking up frequently —we miss out on vital body processes.  This can affect our health and well-being the next day and long term.

What happens if you don’t get enough sleep?

If your body doesn’t get a chance to properly recharge – by cycling through REM and NREM – you’re already starting the next day at a disadvantage. You might find yourself:

  • Feeling drowsy, irritable or sometimes depressed
  • Struggling to take in new information at work, remembering things or making decisions
  • Craving more unhealthy foods, which could cause weight gain1

We have all heard about the importance of sleeping well, and we’ve all experienced the feeling of being refreshed after a good night’s sleep, or the feeling of fatigue after a poor night’s sleep. Even though we know this, in our busy society, many of us are not getting the quality sleep needed to truly receive its health benefits.

Here are a few reasons to catch more ZZZZs.

Healthy Brain Function and Emotional Well-Being

Sleep helps your brain work properly. While you’re sleeping, your brain is preparing for the next day. It’s forming new pathways to help you learn and remember information.

Studies show that a good night’s sleep improves learning. Whether you’re learning math, how to play the piano, how to perfect your golf swing, or how to drive a car, sleep helps enhance your learning and problem-solving skills. Sleep also helps you pay attention, make decisions, and be creative.

Studies also show that sleep deficiency alters activity in some parts of the brain. If you’re sleep deficient, you may have trouble making decisions, solving problems, controlling your emotions and behavior, and coping with change. Sleep deficiency also has been linked to depression, suicide, and risk-taking behavior.

Children and teens who are sleep deficient may have problems getting along with others. They may feel angry and impulsive, have mood swings, feel sad or depressed, or lack motivation. They also may have problems paying attention, and they may get lower grades and feel stressed.

Physical Health

Sleep plays a significant role in your physical health. For example, sleep is involved in healing and repair of your heart and blood vessels. Ongoing sleep deficiency is linked to an increased risk of heart disease, kidney disease, high blood pressure, diabetes, and stroke.

Sleep deficiency also increases the risk of obesity. For example, one study of teenagers showed that with each hour of sleep lost, the odds of becoming obese went up. Sleep deficiency increases the risk of obesity in other age groups as well.

Sleep helps maintain a healthy balance of the hormones that make you feel hungry (ghrelin) or full (leptin). When you don’t get enough sleep, your level of ghrelin goes up and your level of leptin goes down. This makes you feel hungrier than when you’re well-rested.

Sleep also affects how your body reacts to insulin, the hormone that controls your blood glucose (sugar) level. Sleep deficiency results in a higher than normal blood sugar level, which may increase your risk for diabetes.

Sleep also supports healthy growth and development. Deep sleep triggers the body to release the hormone that promotes normal growth in children and teens. This hormone also boosts muscle mass and helps repair cells and tissues in children, teens, and adults. Sleep also plays a role in puberty and fertility.

Your immune system relies on sleep to stay healthy. This system defends your body against foreign or harmful substances. Ongoing sleep deficiency can change the way in which your immune system responds. For example, if you’re sleep deficient, you may have trouble fighting common infections.

Daytime Performance and Safety

Getting enough quality sleep at the right times helps you function well throughout the day. People who are sleep deficient are less productive at work and school. They take longer to finish tasks, have a slower reaction time, and make more mistakes.

After several nights of losing sleep—even a loss of just 1–2 hours per night—your ability to function suffers as if you haven’t slept at all for a day or two.

Lack of sleep also may lead to microsleep. Microsleep refers to brief moments of sleep that occur when you’re normally awake.

You can’t control microsleep, and you might not be aware of it. For example, have you ever driven somewhere and then not remembered part of the trip? If so, you may have experienced microsleep.

Even if you’re not driving, microsleep can affect how you function. If you’re listening to a lecture, for example, you might miss some of the information or feel like you don’t understand the point. In reality, though, you may have slept through part of the lecture and not been aware of it.

Some people aren’t aware of the risks of sleep deficiency. In fact, they may not even realize that they’re sleep deficient. Even with limited or poor-quality sleep, they may still think that they can function well.

Drowsy drivers may feel capable of driving. Yet, studies show that sleep deficiency harms your driving ability as much as, or more than, being drunk. It’s estimated that driver sleepiness is a factor in about 100,000 car accidents each year, resulting in about 1,500 deaths.

Drivers aren’t the only ones affected by sleep deficiency. It can affect people in all lines of work, including health care workers, pilots, students, lawyers, mechanics, and assembly line workers.

As a result, sleep deficiency is not only harmful on a personal level, but it also can cause large-scale damage. For example, sleep deficiency has played a role in human errors linked to tragic accidents, such as nuclear reactor meltdowns, grounding of large ships, and aviation accidents

Get help

If you are shorting your sleep night after night, it places a tremendous strain on your nervous system, body and overall health. Damage from sleep deficiency can occur in an instant (such as a car crash), or it can harm you over time. For example, ongoing sleep deficiency can raise your risk for some chronic health problems. It also can affect how well you think, react, work, learn, and get along with others.

So, if you’re not sleeping well or aren’t feeling rested when you wake up in the morning, it’s important to talk to your doctor and ask if a sleep study is right for you.  To find a healthcare provider who is practiced in helping you get a good night’s rest, go to HealthLynked.com.  In our first of its kind healthcare ecosystem, you will find physicians and advice to help you stop counting sheep!

Sign up for Free and start taking control of your health today!

 

Why is it Important to Know My Family Health History?

Family Health History: Why It’s Important and What You Should Know
Why is it important to know my family history?

by Kimberly Holland

Family members share more than similar appearance. You may recognize that you have your father’s curly hair or your mother’s button nose. Thank goodness my kids got my wife’s food looks. What is not so easy to see is that your great-grandmother passed along an increased risk for both breast and ovarian cancer.

That’s why discovering and knowing your family health history is vitally important. Your medical history includes all the traits your family shares you can’t see. These traits may increase your risk for many hereditary conditions and diseases, including:

• cancer
• diabetes
• asthma
• heart disease and blood clots
• Alzheimer’s disease and dementia
• arthritis
• depression
• high blood pressure and high cholesterol

Whose history do I need?

The general rule for family health history is that more is better. First, you’ll want to focus on immediate family members who are related to you through blood. Start with your parents, siblings, and children. If they’re still alive, grandparents are another great place to start. They may know partial histories of many members of your family.

You can also gather information from your aunts and uncles, and other blood relatives. Once you move beyond this core circle of family, genetic makeups change so greatly that you may not be able to learn much about your own risk. Still, keep information handy for any family members you learn about during your search for medical history. It may be helpful down the road.

How can I gather this information?

Talking about health may not come naturally to you or your family. You can start the conversation by letting your family members know why you want to gather health information. Also, let them know that you’re willing to share information with them, so that you can all have more complete health histories. It may be easier to start out by having one-on-one conversations.

Get the right information

When you’re ready to gather family health history information, keep these things in mind:

Major medical issues: Ask about every major medical issue anyone in close relation to you has been diagnosed with. In this fact-finding stage, nothing is too small, though issues are only significant if the cause was genetic. Lyme disease, injuries, and other things caused by external factors can’t be inherited.
Causes of death: Find out the cause of death for any family members who’ve passed away. That might provide a clue to your family medical history, too.
Age of onset: Ask when each family member was diagnosed with each condition. This may help your doctor recognize the early onset of certain diseases.
Ethnic background: Different ethnicities have varying levels of risk for certain conditions. As best you can, identify your ethnic background to help spot potential health risks.
Environment: Families share common genes, but they also share common environments, habits, and behaviors. A complete family history also includes understanding what factors in your environment could impact your health.

5 questions to ask

Here are some questions you can ask to start the conversation:

  1. How old was my relative when they died, and what was the cause of death?
  2. Are there health problems that run in the family?
  3. Is there a history of pregnancy loss or birth defects in my family?
  4. What allergies do people in my family have?
  5. What is my ethnicity? (Some conditions are common among certain ethnicities.)

What should I do with this information?

Knowing your own health history is important, and sharing it with your doctor may be more important. That’s because your doctor can help you interpret what it means for your current lifestyle, suggest prevention tips, and decide on screening or testing options for conditions you may be more at risk for developing.

The genes you’re born with can’t be changed or altered. If you know your family history, you’re one step ahead of the game. You can take the initiative to adopt healthier lifestyle habits. For example, you could decide to stop smoking or drinking alcohol, or to start exercising regularly and maintaining a healthy weight. These lifestyle changes may reduce your chances for developing hereditary conditions.

Is incomplete information still useful?

Even a family health history that’s incomplete is still useful to your doctor. Share any information you have with them.

For example, if you know that your sibling was diagnosed with colon cancer at age 35, your doctor may suspect a possible genetic issue. They may then decide it’s important that you have regular colon cancer screenings before the recommended age of 50. Your doctor may also suggest you undergo genetic counseling or testing to identify any genetic risks.

What if I was adopted

Environment plays an important part in your health history, and you can get the details for this from your adoptive family. Learning more about your birth family’s health history may require a large investment of time and energy.

Ask your adoptive parents if they have any information about your birth parents. It’s possible family health history information was shared during the adoption process. If not, ask the agency that arranged the adoption if they retained any personal health history information for your birth parents. Understand your state’s statutes before you begin requesting adoption history information.

If all of these avenues come up short, you may need to make a choice about seeking out your birth parents. You may not wish to pursue that route, or you may be unable to connect with them. In that case, alert your doctor to your personal history. The two of you can then work to identify ways to screen for and detect your risk of certain conditions.

What if I’m estranged from my family?

If you’re estranged from only part of your family, you can try a few things to collect your family health history:

Talk to the family members you’re connected with. You may not need to reconnect with your whole family to collect your family health history.
Reach out via your doctor. Some medical offices may be able to send out questionnaires to family members asking for information in an official capacity. This may prompt people to respond.

Do some research. You may be able to discover the cause of death of your relatives from death certificates. Search online to find state-specific death records or check ancestry sites for this information. Obituaries, often available online or archived by public libraries, might also provide health information.

What about genetic testing and genetic predisposition?

Certain ethnic backgrounds and races may be predisposed to conditions for which a genetic test is useful. For example, women of Ashkenazi Jewish ancestry have an increased risk for breast cancer. A specific gene mutation is more common in these women than in other women. Genetic screening may help your doctor detect this gene mutation and prepare you for treatment options early.

Although genetic tests can help identify potential risks you may have inherited for a specific disease, they don’t guarantee you’ll develop that disease. Results may show you have a predisposition to several conditions. While you may never actually develop any of these, you might feel the added anxiety isn’t worth the knowledge. Seriously consider the benefits and concerns you may have with knowing your genetic risk factors before you do any testing.

How do I record the details?

Make sure you write down or electronically document the health information your relatives provide. You can use HealthLynked for this. Just complete one profile per family member whose medical records you are responsible for and have other family members complete and share their own with you.

Outlook

Knowing your health history helps you to be more proactive about your health. Share this information with your doctor so they can screen early for conditions you’re predisposed to and suggest lifestyle choices that can help reduce your risk.



Also talk to your doctor if you need more help figuring out how to uncover your health history or what questions you should ask. If you don’t have one you depend on today, you might find a great physician using the first of its kind social ecosystem designed specifically for everything described in the article.

Ready to get Lynked? Go to HealthLynked.com now to start compiling your medical history and sharing with those you choose, for Free, today!

Source

 

The Beat Goes On | Heart Transplants Still a Marvel of Modern Medicine

On this day in 2001, a petite 44-year-old woman received a successful heart transplant at Ronald Reagan UCLA Medical Center, thanks to an experimental Total Artificial Heart designed for smaller patients.

The UCLA patient was the first person in California to receive the smaller Total Artificial Heart, and the first patient in the world with the device to be bridged to a successful heart transplant — that is, to go from needing a transplant to receiving one.

The 50cc SynCardia temporary Total Artificial Heart is a smaller investigational version of the larger 70cc SynCardia heart, which was approved for use in people awaiting a transplant by the Federal Food and Drug Administration in 2004 and has been used by more than 1,440 patients worldwide.

The 50cc device is designed to be used by smaller patients — including most women, some men and many adolescents — with end-stage biventricular heart failure, where both sides of the heart are failing to pump enough blood to sustain the body. The device provides mechanical support until a donor heart can be found

Nemah Kahala, a wife and mother of five, was transferred to UCLA from Kaiser Permanente Los Angeles Medical Center in March.  She was suffering from restrictive heart muscle disease and in critical condition.  Her heart failure was so advanced that repair surgery and other mechanical assist devices could not help.

Kahala was placed on a life support system called extra corporal membrane oxygenation, but this only works for about 10 days before a person’s organs begin to deteriorate.

With the clock ticking, doctors needed to buy time by replacing Kahala’s failing heart with an artificial heart while she waited for a heart transplant.  Her chest cavity was too small for her to receive the larger 70cc artificial heart.  However, under a one-time emergency use permitted under FDA guidelines, her doctors were able to implant the experimental 50cc device.

“Mrs. Kahala’s condition was deteriorating so rapidly that she would have not survived while waiting for a transplant,” said her surgeon, Dr. Abbas Ardehali, a professor of cardiothoracic surgery and director of the UCLA Heart and Lung Transplant Program. “We were grateful to have this experimental technology available to save her life and help bridge her to a donor heart.”

The artificial heart provides an immediate and safe flow of blood to help vital organs recover faster and make patients better transplant candidates.

After the two-hour surgery to implant the artificial heart, Kahala remained hospitalized in the intensive care unit and eventually began daily physical therapy to help make her stronger for transplant surgery.

Two weeks after the total artificial heart surgery, she was strong enough to be placed on the heart transplant list.  After a week of waiting, a donor heart was found.

“In addition to the high-tech medicine that kept her alive, Mrs. Kahala and her family exemplified how a solid support system that includes loved ones and a compassionate medical team practicing what we at UCLA have termed ‘Relational Medicine’ plays an important role in surviving a medical crisis,” said Dr. Mario Deng, professor of medicine and medical director of the Advanced Heart Failure, Mechanical Support and Heart Transplant program at UCLA.

Kahala was discharged from UCLA on April 18.

Since 2012, the UCLA Heart Transplant Program has implanted eight 70cc SynCardia Total Artificial Hearts. UCLA also participated in the clinical study of a 13.5-pound Freedom portable driver — a backpack-sized device that powers the artificial heart, allowing the patient to leave the hospital — that received FDA approval on June 26, 2014.

The FDA cautions that in the United States, the 50cc SynCardia temporary Total Artificial Heart is an investigational device, limited by United States law to investigational use.  The 50cc TAH is in an FDA-approved clinical study.

First Fully Contained Artificial Heart

On the same day, a patient was implanted with the world’s first self-contained mechanical heart after a 7-hour operation, a hospital in Louisville, Kentucky. The procedure was the first major advance in the development of an artificial replacement heart in nearly two decades.

The device, created by Danvers, Massachusetts-based Abiomed Inc., replaces the lower chambers of a patient’s failing heart with a plastic-and-metal motorized hydraulic pump which weighs 2 pounds (1 kg) and is about the size of a grapefruit.

It was the first artificial heart to be free of wires connecting it to the outside.

“This is the first time this has ever been done,” said Kathy Keadle, a spokeswoman at Jewish Hospital where the procedure was performed by University of Louisville surgeons Laman Gray and

Neither Abiomed nor hospital officials would disclose the name, sex or gender of the patients, all of whom are seriously ill.  The long-awaited surgery had been expected by June 30 but was delayed because the company had not completed patient screening.

Abiomed got U.S. Food and Drug Administration approval in February’s 2001 to test the device on as many as 15 patients, all of whom are too ill to be candidates for a heart transplant.  Unlike existing devices, which serve as a temporary solution to extend a patient’s life until a patient can secure a donor heart, the AbioCor heart is designed to be a fully functioning replacement heart.

The trial involved severely ill patients with less than 30 days to live, said John Thero, vice president and chief financial officer of Abiomed.

“This is not a bridge to transplant. There is a scarcity of donor hearts available,” Thero said in a telephone interview. “We are starting with patients who are at the ends of their lives. They are not candidates for transplant and are near death. Our goal is to provide them with a reasonable quality of life and an extension of life.”

Thero said the current candidates had a life expectancy of two months. “While the device is designed to eventually go much longer, if we were able to double someone’s life expectancy, we would be very pleased,” he said.

The 40,000 patients awaiting heart transplants far outnumber the number of hearts available, and a successful mechanical heart could fill a huge need.

Earlier versions of the artificial heart were bulky and provided limited benefit to patients.  In 1982, Dr. Barney Clark, 61, of Salt Lake City, Utah, received the first permanent artificial heart, known as Jarvik-7. He was bound to his bed by protruding cables, tubes and a noisy box-like air compressor during the 112 days that he survived with the artificial heart.

With the Jarvik-7 and other “bridge devices,” the outside connectors leave patients exposed to infection.  The AbioCor contains a small electric motor attached to an implanted battery and is designed to last for years. Patients could wear a battery pack or plug into an electrical outlet to recharge the heart’s battery.

A Brief History of Heart Transplant

Long before human-to-human transplantation was ever imagined by the public, scientists were conducting pioneering medical and surgical research that would eventually lead to today’s transplantation successes. From the late 1700s until the early 1900s, the field of immunology was slowly evolving through the works of numerous independent scientists. Among the notable breakthroughs were Ehrlich’s discovery of antibodies and antigens, Lansteiner’s blood typing, and Metchnikoff’s theory of host resistance.

Because of advances in suturing techniques at the end of the 19th century, surgeons began to transplant organs in their lab research. At the start of the 20th century, enough experimentation had taken place to know that xenographic (cross species) transplants invariably failed, allogenic transplants (between individuals of same species) usually failed, while autografts (within the same individual, generally skin grafts) were almost always successful. It was also understood that repeat transplants between same donor and recipient experienced accelerated rejection, and that graft success was more likely when the donor and recipient shared a “blood relationship.”

Alexis Carrel was a French surgeon and Nobel laureate whose experiments involved sustaining life in animal organs outside the body. He received the 1912 Nobel Prize in Medicine or Physiology for his technique for suturing blood vessels. In the 1930s, he collaborated with the aviator Charles Lindbergh to invent a mechanical heart that circulated vital fluids through excised organs. Various organs and animal tissues were kept alive for many years in this fashion.

Throughout the 1940s and 50s, small but steady research advances were made. In 1958, Dickinson Richards, MD, chairman of the Columbia University Medical Division, and Andre Cournaud were awarded the same Nobel Prize for their work leading to fuller understanding of the physiology of the human heart using cardiac catheterization.

In that same year, Keith Reemtsma, MD, a member of the faculty of Tulane University who later became chairman of the Department of Surgery at Columbia University Medical Center, showed for the first time that immunosuppressive agents would prolong heart transplant survival in the laboratory setting.

At this time, Norman Shumway, MD, Richard Lower, MD, and their associates at Stanford University Medical Center were embarking on the development of heart-lung machines, solving perfusion issues, and pioneering surgical procedures to correct heart valve defects. Key to their success was experimentation with “topical hypothermia,” the localized hyper-cooling of the heart which allowed the interruption of blood flow and gave the surgeons the proper blood-free environment and adequate time to perform the repairs. Next came “autotransplantation,” where the heart would be excised and resutured in place.

By the mid-1960s, the Shumway group was convinced that immunologic rejection was the only remaining obstacle to successful clinical heart transplantation. In 1967, Michael DeBakey, MD, implanted an artificial left ventricle device of his design in a patient at Baylor College of Medicine in Houston.

In 1967, a human heart from one person was transplanted into the body of another by a South African surgeon named Dr. Christiaan Barnard in Cape Town. In early December, Dr. Barnard’s surgical team removed the heart of a 25-year-old woman who had died following an auto accident and placed it in the chest of Louis Washkansky, a 55-year-old man dying of heart damage. The patient survived for 18 days. Dr. Barnard had learned much of his technique from studying with the Stanford group. This first clinical heart transplantation experience stimulated world-wide notoriety, and many surgeons quickly co-opted the procedure. However, because many patients were dying soon after, the number of heart transplants dropped from 100 in 1968, to just 18 in 1970. It was recognized that the major problem was the body’s natural tendency to reject the new tissues.

Over the next 20 years, important advances in tissue typing and immunosuppressant drugs allowed more transplant operations to take place and increased patients’ survival rates. The most notable development in this area was Jean Borel’s discovery of cyclosporine, an immunosuppressant drug derived from soil fungus, in the mid 1970s.

The cardiac transplant program at Columbia University Medical Center began in 1971 as part of an investigational surgery program initiated by Dr. Keith Reemtsma. At that time, Columbia University Medical Center was one of only a handful of medical centers in the nation actively engaged in cardiac transplant research. Columbia University Medical Center’s first cardiac transplant was performed by Dr. Reemtsma in 1977, when survival rates had begun to improve significantly. That patient survived for 14 months. Two additional transplants were performed that year. Initially Columbia University Medical Center accepted patients deemed too risky for transplantation by Stanford and the Medical College of Virginia, the only other medical centers in the country performing heart transplants.

Thanks to the persistence of pioneers in immunosuppression research, transplant patients have dramatically expanded life expectancies. The first immunosuppressant drugs used in organ transplantation were the corticosteroids. In 1983, Columbia University Medical Center became one of a small group of medical centers to initiate clinical trials of cyclosporine; approved for commercial use in November of that year, it is still the most commonly prescribed immunosuppressant used in organ transplantation. General information on the variety of medications that may be prescribed for you is found in the chapter on Medications in the section Care and Concerns after Your Operation.

In 1984, the world’s first successful pediatric heart transplant was performed at Columbia on a four-year-old boy. He received a second transplant in 1989 and lived until he succumbed to other health issues in 2006.

Also, in 1984, in Loma Linda, California, Leonard Bailey, MD, implanted a baboon heart into a 12-day-old girl who came to be known as “Baby Fae.” The infant survived for twenty days as the most famous recipient of xenographic transplantation. Throughout the decade of the 1980s and into the 90s, physicians continue to refine techniques for balancing dosages of immunosuppressant medications to protect the new heart yet allow the patient sufficient immunologic function to stave off infection. In 1994 a new drug, tacrolimus or FK-506, originally discovered in a fungus sample, was approved for immunosuppression in transplant patients. Newer formulations of cyclosporine now enable efficacy (effectiveness) at lower, less toxic dosages.

While research on transplantation issues continues, other techniques for the management and cure of heart disease are also under development. Some future directions include:

Coronary assist devices and mechanical hearts are being developed or perfected to perform the functions of live tissues. Artificial hearts have been under development since the 1950s. In 1966, Dr. DeBakey first successfully implanted a booster pump as a temporary assist device. Columbia’s cardiac surgeons have been instrumental in the development of a LVAD (left ventricular assist device) to function as a bridge-to-transplantation for those waiting for a new heart to become available. Columbia University Medical Center’s lead role in the REMATCH clinical trial helped to lead to approval for the the LVAD as a permanent, or destination, therapy as well.

In 1969, Dr. Denton Cooley implanted the first completely artificial heart in a human, again on a temporary basis. The first permanent artificial heart, designed by Dr. Robert Jarvik, was implanted in 1982. Numbers of patients have received Jarvik or other artificial hearts since, but surviving recipients have tended to suffer strokes and related problems.

There is a tremendous gap in the number of patients waiting for new hearts and the number of organs that actually become available. In addition to avoiding the immunosuppression and rejection complications of transplantation, success in clinical application of such mechanical devices can help resolve the issue of organ availability and thus, stakes are high to continue research in this arena.

Advances in immunosuppression have most recently involved the development and expanded use of polyclonal and monoclonal antibodies to counteract steroid-resistant rejection. Research continues into the management, reversal and avoidance of accelerated atherosclerosis in the transplanted heart, believed to be caused or aggravated by the required suppression of the body’s normal immunology. From the development of more powerful and specific immunosuppressants to new treatments for accelerated graft atherosclerosis, advances in the science of immunology appear to hold the key to expanding the success of heart transplantation in our treatment of end-stage cardiac disease.

If your ticker needs an update, or you are just feeling a little BLAH, go to HealthLynked.com to find the right physician for you.  We are the world’s first every healthcare ecosystem designed to connect physicians to patients in unique ways for the efficient exchange of information.

Transplant the old ways of finding and sharing with your doctor.  Restore great relational medicine.  Go to Healthlynked.com today and sign up for free!

Sources

UCLAnewsroom.edu

Wired.com

Columbiasurgery.org

Title:  The Beat Goes On | Heart Transplants a Marvel of Modern Medicine

 

#heart,#transplant,#immunosuppression

 

11 Ways Laughter IS the Best Medicine, and It IS Contagious !

Do you remember that last time you had a good, hearty, deep from your very soul laugh? For my family, it was last night while we enjoyed fireworks with friends over the lake in anticipation of the 4th of July celebration. Josh Billings said, “Laughter is the fireworks of the soul”; and great wisdom can be found in Proverb (17:22): “A cheerful heart is good medicine, but a broken spirit saps a person’s strength.”

There are tremendous health benefits found in laughing – it strengthens your immune system, triggers the release of endorphins that lift your mood, helps protect your heart, diminishes pain and protects you by reducing effects of stress.

One of the best feelings in the world is that deep belly laugh – to have one and even to hear it in others. While the ability to laugh is a powerful health resource, mentally, emotionally and physically. it can also bring people together and establish amazing connections. Everything from a slight giggle to a side-splitting guffaw can change the atmosphere of a room from chilly unfamiliarity to warm and family-like. Studies have shown a strong, positive bond is created when we laugh with one another.

So, when was the last time you found yourself laughing out loud? Hopefully, you are one of the fortunate ones that has enjoyed the delights of laughing recently – and the powerful preventive benefits its joy offers. There is so much to love about laughter and many ways it promotes wellness and wellbeing in everyday life, at home, work and at play.

What is laughter?

While the brain mechanisms behind laughing (and smiling) remain a mystery, it is often a spontaneous response to humor or other visual, auditory, or emotional stimuli. And, too, it can occur on command—as either voluntary or contrived.

When we laugh, air is forced through the vocal cords as a result of chest wall contractions, in particular from the diaphragm. It is often followed by a deep inspiration of air. Thus, laughter recruits a number of muscles—respiratory, laryngeal, and facial. And when “exuberant,” it can also involve the arms and legs.

When do humans begin laughing?

Our first laugh typically occurs between 3 to 4 months of age—even before we learn to speak! It is believed that a baby’s laugh serves as a way to communicate, bond, and, too, explore sound and vocalization.
There is already so much to love for laughter that it seems greedy to look for more, but that’s exactly what researchers Dr. Lee Berk and Dr. Stanley Tan at the Loma Linda University in California have done. These two doctors have researched the benefits of laughter and found amazing results.

1. Lowers blood pressure
People who lower their blood pressure, even those who start at normal levels, will reduce their risk of stroke and heart attack. So, grab the Sunday paper, flip to the funny pages, and enjoy your laughter medicine, or pull up the latest memes in social media. Of even better, watch your favorite funny movie, or check out these YouTube posts from LucidChart.

2. Reduces stress hormone levels
By reducing the level of stress hormones, you’re simultaneously cutting the anxiety and stress that impacts your body. Additionally, the reduction of stress hormones may result in higher immune system performance. Just think: Laughing along as a co-worker tells a funny joke can relieve some of the day’s stress and help you reap the health benefits of laughter.

Psychologically, having a good sense of humor—and applying it by laughing—may permit us to have a better perspective on things by seeing situations in a “more realistic and less threatening light.” Physically, laughter can put a damper on the production of stress hormones—cortisol and epinephrine—as well as trigger the release of endorphins. Endorphins are our body’s natural painkillers and can boost our mood. And, too, it has been shown that a good LOL or ROTFL — texting slang for “laugh out loud” or “rolling on the floor laughing” — can relax our muscles for up to 45 minutes after.

3. Works your abs
One of the benefits of laughter is that it can help you tone your abs. When you are laughing, the muscles in your stomach expand and contract, similar to when you intentionally exercise your abs. Meanwhile, the muscles you are not using to laugh are getting an opportunity to relax. Add laughter to your ab routine and make getting a toned tummy more enjoyable.

4. Improves cardiac health
Laughter is a great cardio workout, especially for those who are incapable of doing other physical activity due to injury or illness. It gets your heart pumping and burns a similar number of calories per hour as walking at a slow to moderate pace. So, laugh your heart into health.

The American Heart Association states that laughter can help our hearts. Research shows that by decreasing stress hormones, we can see a decrease in blood pressure as well as artery inflammation and bad cholesterol levels. Elevated blood pressure forces our heart to work harder in order to generate the force needed to pump against the increased resistance. And inflammation and high cholesterol contribute to the development of fatty plaques that decrease blood flow to the heart, or, even, complete blockage that can cause a heart attack.

5. Boosts T-cells
T-cells are specialized immune system cells just waiting in your body for activation. When you laugh, you activate T-cells that immediately begin to help you fight off sickness. Next time you feel a cold coming on, add chuckling to your illness prevention plan.

6. Triggers the release of endorphins
Endorphins are the body’s natural painkillers. By laughing, you can release endorphins, which can help ease chronic pain and make you feel good all over.

7. Produces a general sense of well-being
Laughter can increase your overall sense of well-being. Doctors have found that people who have a positive outlook on life tend to fight diseases better than people who tend to be more negative. Smile, laugh, and live longer!

8. Improves bonding
There has been much written that laughter is not primarily about humor, but, instead, social relationships. When we laugh, we create a positive emotional climate and a sense of connection between two people. In fact, with romantic partners, shared laughter—when you laugh together—is an indicator of relationship well-being, in that it enhances closeness and perceptions of partner supportiveness.

9. Can shed pounds
In a study published in the International Journal of Obesity, researchers found that 15 minutes of genuine laughter burns up to 40 calories, depending on the individual’s body weight and laughter intensity. While this cannot replace aerobic physical activity, 15 minutes of daily LOL, over the course of a year, could result in up to 4 fewer pounds.

10. Enhances our ability to fight off germs
Laughter increases the production of antibodies—proteins that surveillance for foreign invaders—as well as a number of other immune system cells. And, in doing so, we are strengthening our body’s defenses against germs. Additionally, it is a well-known fact that stress weakens our immune system. And because laughing alleviates our body’s stress response, it can help dampen its ill-effects.

11. A natural pain-killer
The iconic Charlie Chaplin stated: “Laughter is the tonic, the relief, the surcease for pain.” Although Mr. Chaplin probably meant this figuratively, laughter can literally relieve pain by stimulating our bodies to produce endorphins — natural painkillers. Laughter may also break the pain-spasm cycle common to some muscle disorders. The best part: You do not need a prescription and there are no known side-effects.

Is it contagious?

Yes. The saying “laugh and the whole world laughs with you” is not just figurative, it is literal. When we hear laughter, it triggers an area in our brain that is involved in moving the muscles in our face, almost like a reflex. This is one of the reasons television sitcoms have laugh tracks—a separate soundtrack that contains the sound of audience laughter. We are more likely to find the joke or situation funny and chuckle, giggle, or guffaw.

How to use laughter to heal and uplift.

Laughter is a physical expression of pleasant emotions among human beings. It is preceded by what one sees, hears or feels. When shared, it serves to connect people and increases intimacy and is a good anti-stress medicine.

LOL or lol, has become a very popular element of internet communications and texting in expressing great amusement in a chat. As well, according to research, the smiling and “tears of joy” laughing emoji faces are tops in digital communications. Their usage is so widespread and so common, that we now actually have data that demonstrates that the use and placement of emojis carries an emotional weight which impacts our perception of the messages that frame these icons (understanding the mental states of others is crucial to communication). And yes, in today’s busy world we may be utilizing =D and LOL’s at every turn, but let’s lean in to the hilarious and enjoy the good, hearty health benefits of laughter.

And remember, know when not to laugh. Laughter at the expense of others or in hurtful situations is inappropriate.

Now, make a commitment to laugh more.

In his book, The Travelers Gift, Andy Andrews challenges the traveler to start each day with laughter within moments of waking. It changes your whole being, even if you only laugh for seven seconds. I have tried it. I have faked it, and even as I start with the fake laugh, I can’t stop after seven seconds.

Practice laughing by beginning with a smile and then enact a laugh. Although it may feel contrived at first, with practice, it will likely become spontaneous. At Laughter University (yes, there is one) they encourage at least 30 seconds. There is so much going on around us that is laughable!

We can also move towards laughter by being with those who laugh and return the favor by making them laugh. And, too, surround ourselves with children and pets. On average, children laugh 300 times a day! And we know that laughter is contagious. Studies have shown people are immensely happier just seeing a picture of a dog!

Even make an effort to find the humor in an unpleasant situation, especially with situations that are beyond our control.

For all this, you will be made glad. Laughter wipes away stress, decreases blood pressure, burns calories, alleviates pain, connects us to others, reinvigorates us with hope, helps ward off germs … (the list goes on) – and feels soooo good. LOL for better health, connection and joy!

Want to find a physician who tickles your funny bone or at least knows where it is?  Find them in the fastest growing HealthCare ecosystem around.

HealthLynked is the first of its kind network designed to connect patients with their physicians for a higher purpose – Improving HealthCare!

Ready to get Lynked?  Got to HealthLynked.com to sign up for free!

Sources:
Gaiam.com
laughteronlineuniveristy,com
Dr. Nina Radcliff, Laugh, giggle, be joyful — for lol; ‘The fireworks of the soul’. Washington Post

Relativity, Radiology and 6 Things You May not Know About Einstein

More than any other profession, radiologists and radiologic technologists put theoretical quantum physics to practical use Improving the health and lives of their patients. Although quantum light theory can explain everything from the tiniest subatomic particles to immense galaxy-devouring black holes, radiologists apply this technology at the human level to diagnose and treat disease and thus alleviate human suffering.

More than 100 years ago in 1895, Wilhelm Conrad Roentgen discovered a form of radiation which had strange new properties. These new rays were so unique and mysterious that he named them “X-rays”, for the unknown. Although often described as a fortuitous discovery, chance favors the prepared mind, and Roentgen’s astute observations back then are still accurate today.

X-rays

6 Things You May not Know About Einstein
Digital portrait of Wilhelm Roentgen holding a cathode ray tube. Image by Mark Hom
  • transmit in complete darkness
  • invisible to the human eye
  • originate from a cathode ray tube
  • expose covered photographic plates
  • diminish in intensity following the inverse square law of light emission
  • soft tissues appear trans­parent, but metal and bone appear opaque.
  • transparency of intervening objects depends on their molecular density and thickness
  • not reflected by mirrors nor deflected by glass prisms
  • travel at a constant speed – the speed of light
  • share some properties with visible light, yet also have uniquely different properties

For the very first time, doctors (without using a scalpel) could see beyond the skin surface of their patients and peer deep inside the human body. It was later found that X-rays were a form of electromagnetic radiation with wavelengths shorter and with energies greater than visible light.

Subsequent research into particle theory by Albert Einstein and others led to the physics principles that not only laid the groundwork for state-of-the-art medical imaging but also changed the understanding of our entire universe, from the mechanics of the atom to the largest objects in the universe. In 1901, Roentgen received the very first Nobel Prize awarded in physics, an indication that his discovery of a form of invisible light was the beginning of a remarkable scientific journey.

Albert Einstein

Albert Einstein’s theories of relativity soon followed and would explain the space time continuum and the equivalence of mass and energy. Throughout his brilliant career, Einstein was fascinated and preoccupied with the strange properties of light. Einstein once said, “For the rest of my life I will reflect on what light is.”

His concept of special relativity came to him when he was riding his bicycle towards a lamp post. He realized that the speed of light was the only constant for all observers and that the classic Newtonian measurements of mass, distance, and time were all subject to change at velocities approaching the speed of light. Einstein’s relativity means that the science fiction adventures of galaxy-hopping space travel in Star Trek and Star Wars are mere fantasy. The vast distances of space and the universal speed limit of light make intergalactic travel too impractical. If a hypothetical space craft approaches the speed of light, time slows, length compresses, the mass of the space craft increases, and impossibly high amounts of energy are required. At a certain point, the space craft stops accelerating, despite greater and greater energy input.

A result of Einstein’s special theory of relativity has been called the most famous equation in all of science. Energy (E) equals mass (m) multiplied by the speed of light squared (c2), that is E=mc2. This simple equation, which states that energy and mass are interchangeable quantities, is often misinterpreted as the formula of the atomic bomb. The principle of the atomic bomb is bom­bardment of a uranium atom with a neutron that splits the uranium atom into two smaller atoms and more neutrons that trigger a fission chain reaction. Although tremendous energy is released, it is the energy of internuclear binding forces, and there is no appreciable change in mass.

A much better demonstration of E=mc2 is the physics of positron emission tomography (PET scan­ning), in which an electron and positron (the antiparticle of an electron) annihilate each other and convert their masses into pure light energy, consisting of photons traveling in opposite directions. This light is detected and calculated as a three-dimensional image of the patient. Einstein was another founder of radiology because his theory of the Photoelectric Effect (published in 1905 and awarded the Nobel Prize in 1921) explained how X-rays interact with matter. This theory also showed that light was absorbed and emitted in discreet packets of energy, leading to the Quantum Theory revolution in physics. 6 Things You May not Know About Einstein

Here are a few more interesting things to know about Einstein’s theory of relativity:

  1. Einstein relied on friends and colleagues to help him develop his theory. 
    Though the theory of general relativity is often presented as a work of solo genius, Einstein actually received considerable help from several lesser-known friends and colleagues in working on the math behind it. College friends Marcel Grossmann and Michele Basso (Einstein supposedly relied on Grossmann’s notes after skipping class) were especially important in the process. Einstein and Grossman, a math professor at Swiss Polytechnic, published an early version of the general relativity theory in 1913, while Besso—whom Einstein had credited in the acknowledgments of his 1905 paper on the special theory of relativity—worked extensively with Einstein to develop the general theory over the next two years. The work of the great mathematicians David Hilbert—more on him later—and Emmy Noether also contributed to the equations behind general relativity. By the time the final version was published in 1916, Einstein also benefited from the work of younger physicists like Gunnar Nordström and Adriaan Fokker, both of whom helped him elaborate his theory and shape it from the earlier version.
  2. The early version of the theory contained a major error. 
    The version published by Einstein and Grossmann in 1913, known as the Entwurf (“outline”) paper, contained a major math error in the form of a miscalculation in the amount a beam of light would bend due to gravity. The mistake might have been exposed in 1914, when German astronomer Erwin Finlay Freundlich traveled to Crimea to test Einstein’s theory during the solar eclipse that August. Freundlich’s plans were foiled, however, by the outbreak of World War I in Europe. By the time he introduced the final version of general relativity in November 1915, Einstein had changed the field equations, which determine how matter curves space-time.
  3. Einstein’s now-legendary paper didn’t make him famous—at first. 
    The unveiling of his masterwork at the Prussian Academy of Sciences—and later in the pages of Annelen Der Physik—certainly afforded Einstein a great deal of attention, but it wasn’t until 1919 that he became an international superstar. That year, British physicist Arthur Eddington performed the first experimental test of the general relativity theory during the total solar eclipse that occurred on May 29. In an experiment conceived by Sir Frank Watson Dyson, Astronomer Royal of Britain, Eddington and other astronomers measured the positions of stars during the eclipse and compared them with their “true” positions. They found that the gravity of the sun did change the path of the starlight according to Einstein’s predictions. When Eddington announced his findings in November 1919, Einstein made the front pages of newspapers around the world.
  4. Another scientist (and former friend) accused Einstein of plagiarism. 
    In 1915, the leading German mathematician David Hilbert invited Einstein to give a series of lectures at the University of Gottingen. The two men talked over general relativity (Einstein was still having serious doubts about how to get his theory and equations to work) and Hilbert began developing his own theory, which he completed at least five days BEFORE Einstein made his presentation in November 1915. What began as an exchange of ideas between friends and fellow scientists turned acrimonious, as each man accused the other of plagiarism. Einstein, of course, got the credit, and later historical research found that he deserved it: Analysis of Hilbert’s proofs showed he lacked a crucial ingredient known as covariance in the version of the theory completed that fall. Hilbert actually didn’t publish his article until March 31, 1916, weeks after Einstein’s theory was already public. By that time, historians say, his theory was covariant.
  5. At the time of Einstein’s death in 1955, scientists still had almost no evidence of general relativity in action. 
    Though the solar eclipse test of 1919 showed that the sun’s gravity appeared to bend light in the way Einstein had predicted, it wasn’t until the 1960s that scientists would begin to discover the extreme objects, like black holes and neutron stars, that influenced the shape of space-time according to the principles of general relativity. Until very recently, they were still searching for evidence of gravitational waves, those ripples in the fabric of space-time caused (according to Einstein) by the acceleration of massive objects. In February 2016, the long wait came to an end, as scientists at the Laser Interferometer Gravitational Wave Observatory (LIGO) announcedthey had detected gravitational waves caused by the collision of two massive black holes.
  6. You can thank Einstein for GPS. 
    Though Einstein’s theory mostly functions among things like PET scanners and in the black holes and cosmic collisions of the heavens, on an ultra-small scale (think string theory), it also plays a role in our everyday lives. GPS technology is one outstanding example of this. General relativity shows that the rate at which time flows depends on how close one is to a massive body. This concept is essential to GPS, which takes into account the fact that time is flowing at a different rate for satellites orbiting the Earth than it is for us on the ground. As a result, time on a GPS satellite clock advances faster than a clock on the ground by about 38 microseconds a day. This might not seem like a significant difference, but if left unchecked it would cause navigational errors within minutes. GPS compensates for the time difference, electronically adjusting rates of the satellite clocks and building mathematical functions within the computer to solve for the user’s exact location—all thanks to Einstein and relativity.

Quantum Theory

Following Einstein’s ideas that light was transmitted in packets of energy, Niels Bohr and Werner Heisenberg developed a model of the atom that diverged from classic Newtonian physics. The Rutherford atomic model consisting of electrons orbiting the central nucleus was inadequate because charged particles changing direction in an orbit would lose energy and fall into the nucleus. Bohr’s model had to explain the Photoelectric Effect, chemical reactions, and the inherent stability of atoms.

A carbon atom can undergo countless chemical reactions yet remains a carbon atom. As Bohr further investigated the atom, the simplistic idea of light just being a wave and electrons just being particles was no longer valid. With the Photoelectric Effect, Einstein showed that light could be a photon particle. Louis de Broglie then showed that particles could be waves. Both photons and electrons have particle-wave duality. The electron therefore could exist as a standing wave around the nucleus, absorb and emit quanta of light energy, and yet remain stable.

The paradoxes that resulted from Bohr’s quantum theory shook the foundations of science. Werner Heisenberg found that the method of investiga­tion alters the result of an experiment. He explained this idea mathematically in his Uncertainty Principle, which remains a major tenet of quantum mechanics. The light used to measure particles imparts energy, altering the momentum or location of the particles, thus changing the results by the mere act of obser­vation. An experiment can be designed to measure either momentum or location precisely, but not both (the experimenter must choose).

“The violent reaction on the recent development of modern physics can only be understood when one realizes that here the foundations of physics have started moving; and that this motion has caused the feeling that the ground would be cut from science.” – Werner Heisenberg

This finding was unsettling for physicists who strove for precise measurements, because precision was not possible at the atomic and subatomic levels. Heisenberg showed that every experiment (and radiologic examination) is subject to limitation. Einstein objected to this inherent fuzziness, stating that “God does not play dice with the Universe.”

The Doppler Effect

Christian Doppler was a professor who studied mathematics, physics, and astronomy. He published a paper on spin­ning binary star systems, noting that starlight shifts to the violet spectrum when a star is moving toward an observer on Earth, and that starlight shifts to the red when a star is moving away. The explanation was that the wavelength of the light wave was compressed or elongated depending on the motion of the source relative to the observer.

When the Doppler Effect is applied to sound, it explains the tone of an approaching or departing train whistle; when applied to radar it pre­dicts violent weather; when applied to ultrasound (another radiology modality) it determines the direction and velocity of blood flow; and when applied to distant starlight it explains our expanding (red shifted) universe. Using Doppler ultrasound, a technologist can screen for: the risk of stroke from carotid artery stenosis, renal arterial causes of hypertension, abdominal aortic aneurysms, periph­eral vascular disease, deep vein thrombosis, portal vein thrombosis and varices, and post-catheterization pseudo-aneurysms.

Countless lives have been saved or improved because of a phenomenon originally observed in starlight. Doppler’s idea extends well beyond the sonography suite and even tells us about the origins of our universe. Edwin Hubble demonstrated that all objects observed in deep space have a Doppler red-shifted veloc­ity that is proportional to the object’s distance from the Earth and all other interstellar bodies. This tells us that our universe is expanding and supports the theory that the universe was created by the Big Bang, which occurred about 13.7 billion years ago.

Old Master Painters

Artists such as Rembrandt and Vermeer (17th century) were adept at depicting light to create the illusion of realistic three-dimensional subjects on two dimensional canvases. These artists studied the interaction of light with their models and understood visual percep­tion of subtle shading and light to make their artwork dramatic and convincing.

Rembrandt van Rijn’s famous por­traits and self-portraits displayed skill with light source positioning and intensity, later duplicated by movie director Cecil B DeMille who coined the term “Rembrandt lighting,” a technique that is still used today by portrait photographers. Johannes Vermeer was skilled at depicting subjects in naturally lit interiors with a subtle photorealistic style that is con­sidered uncanny even today.

Some believe Vermeer used special optics and mirrors because his depiction of light was too subtle for the naked eye to detect.  For example, scientific analysis showed that his backgrounds demonstrated the inverse square law, with exponential diffusion of light, which is difficult to capture when using only an artistic eye.

Experienced radiologic technologists use artistic vision when they create radiographs. By positioning and framing their subjects and by adjusting contrast and exposure, each image can be a work of art, not only pleasing to the eye but also containing a wealth of infor­mation.

Light as the Medium for Medical Imaging

Light, as visual information, is portrayed in art. Light also is the medium for medical imaging, whether in the form of a backlit film, cathode ray tube monitor, liquid crystal display screen, or plasma monitor. The eye is our most complex and highly evolved sense organ, capable of detecting subtle changes in light and color, and transferring this information (via the optic nerves and optic tracts) to the visual cortex of our occipital lobes.

However, what distinguishes artists and seasoned radiology professionals from other people is post-pro­cessing (i.e., the thinking that occurs after perceiving visual data). Much of science and medicine is about logic, language, analysis, and categorization (left brain functions). However, visual processing (the artistic eye) is about conceptualization, spatial orientation, and pattern recognition (right brain functions). These right brain skills are harder to teach and measure but are just as important in radiology.

With the rapid increases in digital image resolution and in the number of multi-planar images involved with each case, developing the right brain is crucial to make sense of this visual information overload. Knowingly or unknowingly, seasoned radiologists develop the right side of their brains through the experience of viewing thousands of medical images. This “artistic eye” can be further enhanced in radiolo­gists and radiologic technologists who appreciate the techniques used by great artists. Or better yet, they can train their right brains by creating original art themselves.

Conclusion

Radiologists and radiologic technologists use light technology and artistic vision in their daily work. They sense subtle shades, recognize patterns, and use symmetry and bal­ance to detect abnormalities. When this artistic skill is applied in combination with an appreciation for the underlying physics that created the images, a thorough knowledge of human anatomy, and an understanding of the pathophysiology of disease, they serve their patients by providing timely diagnosis and excellent medical care.

Sources:  This is the synthesis of two articles:

[1]  PRUITT, SARAH.  6 Things You Might Not Know About Einstein’s General Theory of Relativity, MARCH 18, 2016, History.com

[2]  Hom, Mark. Radiology: Combining Quantum Theory, Medicine, and Artistic Vision, http://scitechconnect.elsevier.com/radiology-quantum-theory-medicine, January 25, 2016

More Information

For more about Dr. Hom’s writings, concepts, and artwork, please refer to his recent articles and book:

The Art and Science of Light: An Illustrated Retrospective, Mark Hom, Radiologic Technology, July/Aug 2015 86 (6), 702-708.
The Artistic Eye and the Radiologist, Mark Hom, American Roentgen Ray Society, Senior Radiologists Section Notes, Fall 2014.
The Science of Fitness: Power, Performance, and Endurance, Greg LeMond and Mark Hom, Publisher: Elsevier, December 2014.

This article first appeared on Memeburn.comClick here for the original.

Dr. Mark Hom is a Johns Hopkins University trained biologist, an award-winning medical illustrator, an interventional radiologist, an educator of young doctors, an Elsevier author, and an avid fitness cyclist. Dr. Hom’s work with Greg LeMond in their recent book The Science of Fitness: Power, Performance, and Endurance explains how the human body, various organ systems, and individual cells function in the biologic process of exercise. He is currently a member of the Department of Radiology at Virginia Commonwealth University in Richmond, VA, USA.

 

  Disruptive Technology Turns 11; Creator Set to Break Through $1T

It  was the worst kept tech secret of all time; and though everyone knew it was coming,  no one predicted how the iPhone would change the world.  11 years after its launch, Apple is now poised to become the first ever $1T company.

While people published rumors and others guessed at design, buyers began to camp outside stores days in advance to snag a $600 device they’d never seen. Before its release, the hype for an Apple-devised phone was off the scale. It even garnered the nickname the “Jesus phone” — or “jPhone”.  Some felt it would be miraculous, while most believed it could in no way live up to the hype.

It wasn’t the first time in tech history a frenzy was create over a new device. The first whispers came in the summer of 1944: a Hungarian inventor living in Argentina had created something sensational. On the day of its release, New Yorkers “trampled on another” in 1945 to buy the first commercially available ballpoint pens, where they paid the equivalent of $175 in today’s money. That was for a pen, not an Ubersmart mobile device that connects you to the universe.

Despite drawing hordes of fans, the iPhone didn’t immediately charm its way into the mainstream because of its high price tag. Just two months after the iPhone’s initial release, Apple trimmed the handset’s price down to $400. That helped a little, but it wasn’t until 2008 — when Apple unveiled the iPhone 3G with a new $200 price tag and access to the faster 3G network — that the smartphone exploded in popularity. Apple sold over 10 million iPhone 3G units worldwide in just five months.

It wasn’t the faster network or the price tag that really set the iPhone ahead of its competitors. Apple’s core philosophy, then and now, is that software is the key ingredient; and the operating system lying beneath the iPhone’s sleek and sexy touchscreen broke new ground. Unlike other cellphones’ software, the iPhone’s operating system was controlled by Apple rather than a mobile carrier.

Just as the Apple II in 1977 was the first computer made for consumers, the iPhone was the first phone whose software was designed with the user in mind. It was the first phone to make listening to music, checking voicemail and browsing the web as easy as swiping, pinching and tapping a screen — pleasant like a massage.

“An iPod, a phone, an internet mobile communicator,” Jobs said when preparing to introduce the iPhone in 2007. “An iPod, a phone, an internet mobile communicator…. These are not three separate devices!”  Apple put a miniature computer in consumers’ pockets.

But that wasn’t enough for iPhone users. Operating on a closed platform, the iPhone was limited to the few apps that Apple offered — and the handset was restricted to one U.S. carrier — AT&T. The iPhone’s software limitations gave birth to an underground world of hackers seeking to add third-party applications, known as the Jailbreak community. And the AT&T exclusivity created a subset of that hacker community focusing on unlocking the iPhone to work with various carriers — today famously known as the iPhone Dev-Team.

Apple did benefit tremendously from iPhone hackers. The company learned from the Jailbreak community that third-party applications were in high demand and would add even more appeal to the phone. This revelation led to Apple opening its iPhone App Store, which launched concurrently with the second-generation iPhone, iPhone 3G.

Fast forward.  The iPhone turned out to be a game-changer – the proverbial paradigm shift wrapped in a sleek black case housing powerful innovative technology.  It has gone on to Impact the lives of hundreds of millions of people around the world, changing the way we communicate, work, learn and play.

77.3 Million iPhones were sold in the fourth quarter of 2017.  Assuming that each boxed iPhone weighs approximately 500g, give or take, that’s around 39,000 metric tons of iPhones, which is the equivalent of 630  Abrams M1A2 battle tanks.  The Sales volume works out to almost ten iPhones a second, and they sold for an average of $796.  This is how Apple will likely crest $1T this year.

Just like that, Apple flipped cellphone business on its head and transformed mobile software into a viable product. But the most surprising thing about the iPhone is the impact it’s had on six major industries.

The PC Industry –  Apple’s stroke of genius was to put one in your pocket. Until the iPhone shipped, PC sales were around 400 million a year.  As the iPhone and smartphones in general have become critical tools for information, used for productivity, communications and pleasure, the PC has become less important to many people. Until the mobile revolution that came with the iPhone, the only way people could access the Internet was from a PC or laptop.

Today, thanks to the iPhone, iPad and all the Android equivalents inspired by Apple’s ideas, people have many more options to make the connections they need regardless of location. Consequently, the PC industry is now shipping only about 275 to 290 million PCs a year, and this has caused a level of industry consolidation that is now concentrated around Lenovo, HP, Dell, Acer and Apple.

Telecom – Before the iPhone, most of the original telco business models were around voice. Voice over IP became popular by 2000 and had already started pushing the telecom companies to move to digital voice instead of traditional landline voice delivery methods. But with the advent of the iPhone, they were effectively forced out of the traditional voice business altogether.  While there were millions of payphones in place a decade ago, Try and locate a payphone today.

Now, telecom providers are data communications companies whose business models have been completely transformed. All have added things like information and entertainment services, and all have become conduits for multiple types of data services to their customers.

Movie and TV – In order to watch a movie, you once  had to go to a movie theater; and to watch a TV show, you had to sit in front of my television at home and scan three channels….plus PBS.  The iPhone created a mobile platform for video delivery, and since 2007, every major movie and TV studio has been forced to expand their distribution methods to include downloaded and streaming services to mobile devices.

We can thank the millions of iPhones in the field, capable of letting people watch video anytime and anywhere, for prodding these studios to make this so. We can also thank the iPhone for fueling new types of video services like YouTube, Netflix and Hulu — video powerhouses, at least 50% of whose content is viewed on some type of mobile device.

Software distribution.  With the launch of the App Store, Apple shook up the mobile industry again by reinventing software distribution. Apple designed the App Store’s model with a do-it-yourself mentality: All software developers had to do was code an interesting app, submit it to the App Store for approval and market the app however they wished.

The App Store’s method is proving far more effective than the old-fashioned computer shareware model, where developers would offer a free trial of their apps and then cross their fingers that consumers would eventually pay. The shareware model especially didn’t help independent coders, whose apps got trampled on by large software companies with fatter marketing budgets.

Video Gaming.  Before 2007, most games were either delivered by way of game consoles, a PC or a dedicated handheld device like the Nintendo DS or Sony PlayStation Portable. The iPhone expanded the market for mobile games as well as created an entirely new category of touch-based gameplay, persuading even holdouts like Nintendo to come aboard with games based on its iconic franchises.

And though the mobile dominant free-to-play model fractionalizes revenue, the potential for brand exposure is unprecedented: Niantic’s augmented reality-angled Pokémon Go alone has been downloaded over 750 million times. Contrast with Nintendo’s entire Mario franchise’s lifetime sales of just over 500 million.

HealthCare. Today, one can use an iPhone to monitor various health metrics as well as access detailed health information, connecting with health professionals and even receiving health advice virtually anytime and anywhere across a number of different applications.  And we’ve only begun to see how smartphones can impact the health industry – an impact that will doubtless expand as this industry embraces the smartphone for outpatient care.

And HealthLynked will be a huge part of this.  We are not unlike the iPhone.  Where multiple apps do one thing, we are combining all that makes mobile health great into one easy to use, secure platform.  It’s sort of a Swiss Army knife, meets iPhone meets medicine, wrapped in the sleek, easy to use interface of a social platform.  You can find it in the Apple Store.

Ready to start taking control of your health in ways never thought possible?  Get Lynked!  Go to HealtheLynked.com to sign up For Free!



Sources:  Blending the two fantastic articles below.

JUNE 29, 2007: IPHONE, YOU PHONE, WE ALL WANNA IPHONE, by  Brian X. Chen.  Brian wrote a book about the always-connected mobile future called Always On (published June 7, 2011 by Da Capo). Check out Brian’s Google Profile.

 

How Apple’s iPhone Changed These 5 Major Industries, By TIM BAJARIN June 26, 2017.  Tim is recognized as one of the leading industry consultants, analysts and futurists, covering the field of personal computers and consumer technology. Mr. Bajarin is the President of Creative Strategies, Inc and has been with the company since 1981 where he has served as a consultant providing analysis to most of the leading hardware and software vendors in the industry.

 

Photo: Young Steve Jobs
Credit: Ben Lovejoy in Tim Cook Tweets, 9to5Mac

 

Title:  Disruptive Technology Turns 11; Creator Set to Break Through $1T

 

#apple,#iPhone,#healthcareIT,#healthcarereform,#healthcareITreform

 

 

The Often Misunderstood Diagnosis of Post Traumatic Stress Disorder

PTSD stands for Post-Traumatic Stress Disorder and is a condition that many veterans and non-veterans alike suffer; PTSD can occur when someone experiences or witnesses a traumatic event. This condition wasn’t always understood properly by the medical or military community, and Department of Defense press releases often point to earlier attempts to identify PTSD symptoms in the wake of service in World War 2, Vietnam, and other conflicts.

PTSD Awareness Day is observed today, Wednesday, June 27, 2018.

The History of PTSD Awareness Day

In 2010, Senator Kent Conrad pushed to get official recognition of PTSD via a “day of awareness” in tribute to a North Dakota National Guard member who took his life following two tours in Iraq.

Staff Sergeant Joe Biel died in 2007 after suffering from PTSD; Biel committed suicide after his return from duty to his home state. SSgt. Biel’s birthday, June 27, was selected as the official PTSD Awareness Day, now observed every year.

How Do People Observe Post-Traumatic Stress Disorder Awareness Day?

Much of what is done to observe PTSD Awareness Day involves encouraging open talk about PTSD, its’ causes, symptoms, and most important of all, getting help for the condition. When today, PTSD is often misunderstood by those lacking firsthand experience with the condition or those who suffer from it. PTSD Awareness Day is designed to help change that.

The Department of Defense publishes circulars, articles, and other materials to help educate and inform military members and their families about the condition. The Department of Veterans Affairs official site has several pages dedicated to PTSD, and when military members retiring or separating from the service fill out VA claim forms for service-connected injuries, illnesses, or disabilities, there is an option to be evaluated for PTSD as a part of the VA claims process.

What Is Post-Traumatic Stress Disorder?

The current American Psychiatric Association’s Diagnostic and Statistical Manual, DSM-IV, says PTSD can develop through a range of exposures to death or injury: direct personal involvement, witnessing it or, if it concerns someone close, just learning about it.  Post-traumatic stress disorder is a form of anxiety that can happen after experiencing or witnessing actual or near death, serious injury, war-related violence, terrorism or sexual violence.  While most people typically connect this disorder to military veterans or refugees, it can happen to anyone.

Almost no other psychiatric diagnosis has generated as much controversy.  The diagnosis is almost four decades old.  PTSD is not a sign of weakness, and people can be affected by PTSD even when they were not directly part of the traumatic event.

The specific nature of the trauma can and does vary greatly. Experts are quick to point out, while combat and combat-related military service can be incredibly challenging, and while witnessing or being a victim of an event that rips the fabric of daily life can be traumatic, not everyone responds the same way. Some may develop symptoms of PTSD, while others may be unaffected.

Post-Traumatic Stress Disorder: How Widespread Is It?

Some sources estimate that as many as 70% of all Americans have experienced a traumatic event sufficient to cause PTSD or PTSD-like symptoms. That does not mean that all 70% of Americans WILL suffer from PTSD. Using these statistics, some 224 million Americans have experienced a traumatic event. Of that number, some 20% will develop PTSD symptoms, roughly 44 million people.

Of that 44 million, an estimated eight percent experience active PTSD symptoms at any one time. An estimated 50% of all mental health patients are also diagnosed with Post-Traumatic Stress Disorder.

PTSD: Often Misunderstood and Misidentified

“Shell shock” and “combat shock” were earlier attempts to define and understand the symptoms of PTSD. Post-traumatic stress disorder was often stigmatized in popular culture after the Vietnam conflict, and many films and television shows featured antagonists or unsympathetic characters suffering from “Vietnam flashbacks” or other issues.

The misunderstanding of PTSD slowly began to change in 1980 when it was recognized as a specific condition with identifiable symptoms. It was then the disorder was listed in the American Psychiatric Association’s Diagnostic and Statistical Manual of Mental Disorders (DSM).

This manual is a diagnostic tool for mental health professionals and paraprofessional workers in the healthcare field and is considered a definitive reference. The addition of PTSD to the DSM was a highly significant development.

Today, the symptoms of Post Traumatic Stress Disorder are better understood, treatable, and recognized by the Department of Veterans Affairs as a service-connected condition. PTSD is not exclusive to veterans or currently serving members of the United States military, but a portion of those who serve are definitely at risk for PTSD.

What Are the Symptoms of Post-Traumatic Stress Syndrome?

Some PTSD symptoms may seem vague and non-specific, others are more readily identified specifically as evidence of PTSD. In this context “non-specific” means that the symptoms may be related to other mental health issues and not specifically limited to Post-Traumatic Stress Disorder.

In the same way, more “specific” symptoms may be manifest outside PTSD, but when looking for specific signifiers, these issues are common “red flags” that indicate PTSD may be the cause of the suffering rather than a different condition. This is often circumstantial, and there is no one-size-fits-all diagnosis for the condition.

Suicidal thoughts or self-destructive acts are often a result of PTSD or related symptoms. Anyone experiencing thoughts or urges to self-harm should seek immediate care to prevent the condition from getting worse in the short-term. (See below)

That said, more non-specific symptoms include varying degrees of irritability, depression, and suicidal feelings. More specific problems-especially where veterans and currently serving military members are concerned-include something known as “hypervigilance” or “hyperarousal”.

Other symptoms include repeatedly experiencing the traumatic event(s) in the form of flashbacks, nightmares, persistent memories of the event(s), and intrusive thoughts about the traumatic event(s).

These symptoms vary in intensity depending on the individual and are not ‘standardized”. They may come and go, or they may be persistent over a span of time. Sometimes PTSD sufferers can be high-functioning, other times they may be more debilitated by the condition.

Get Treatment For PTSD

Those who experience symptoms of PTSD or PTSD-like issues should seek help immediately. Department of Veterans Affairs medical facilities, private care providers, counselors, and therapists can all be helpful in establishing an initial care regimen or refer those suffering from PTSD to a qualified care provider.

The Department of Veterans Affairs has more information on help for PTSD on its’ official site including help finding a therapist.

Those experiencing suicidal feelings or self-destructive urges should get help immediately. The Suicide Crisis Hotline (1-800-273-8255) has a specific resource for veterans and the Department of Veterans Affairs offers a Veterans’ Crisis Hotline confidential chat resource.

You might also find a healthcare provider using the first of its kind medical ecosystem designed to help you more efficiently Connect and collaborate with your medical team.  Safe, secure and easy to use, HealthLynked is the future of healthcare, here today.

Ready to get Lynked?  Go to HealthLynked.com to sign up for Free and get help, right now!

 

Adapted from https://militarybenefits.info/ptsd-awareness-day/